Type 3 Hypersensitivity

Question 1

What is the target of Type 3 Hypersensitivity?

Answer 1

Soluble Antigens

Question 2

What Does Type 3 Hypersensitivity involve in regards to immune complexes?

Answer 2

Involves IgG or IgM and antigens

Question 3

What is the time scale of Type 3 hypersensitivity?

Answer 3

3-8hrs

Question 4

What causes damage in Type 3 hypersensitivity?

Answer 4

Immune complex deposition

Question 5

What dictates the damage cause in Type 3 hypersensitivity?

Answer 5

• Complex size: Intermediate size immune complexes aren’t cleared and deposited in joints, kidneys, small vessels and skin
• Host Responses: Low Affinity Antibody, Complement Deficiency
• Local Tissue Factors: Haemodynamic Factors, Physicochemical Factors

Question 6

What are examples of diseases caused by Type 3 Hypersensitivity?

Answer 6

• Rheumatoid Arthritis
• Glomerulonephritis
• Systemic Lupus Erythematosus