Type 2 Hypersensitivity Flashcards
1
Q
What is the target of Type 2 Hypersensitivity?
A
Cell-Bound antigen
2
Q
What are examples of Cell-Bound antigens?
A
Exogenous: Blood group antigens, Rhesus D antigens)
Endogenous: self-antigens
3
Q
What does Type 2 hypersensitivity involved in regards to immune system?
A
- IgG or IgM antibodies
- Complement Activation
4
Q
What is the role of IgG or IgM antibody activation?
A
-Antibody dependant cell cytooxicity
5
Q
What does complement activation involve?
A
- Cell lysis through membrane attack complex
- Neutrophil recruitment/activation (C3a/C5a)
- Opsonisation (C3b)
6
Q
What is the time scale of Type 2 hypersensitivity reactions?
A
5-12 hours
7
Q
What are the outcomes of Type 2 Hypersensitivity?
A
- Tissue/Cell damage
- Physiological Change
8
Q
What are disease examples of Type 2 Hypersensitivity Reactions?
A
- Haemolytic Disease of the new-born: Rhesus D
- Transfusion reactions: A/B antigens
9
Q
What is Type 2 Hypersensitivity?
A
Cell-Bound Antigen
