Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BMS 501 > Type 2-4 Hypersensitivity > Flashcards

Type 2-4 Hypersensitivity Flashcards

1
Q

What type of antigen is associated with type II hypersensitivity?

A

a cell surface antigen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What antibodies are associated with type 2 hypersensitivity?

A

IgG and sometimes IgM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What do the clinical signs of type 2 hypersensitivity result from?

A

the destruction or dysfunction of the target cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the cellular targets for type 2 hypersensitivity?

A

red blood cells, skin, neuromuscular junction, and platelets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the mechanisms for destruction of cells/tissues in type 2 hypersensitivity reactions?

A

complement fixation and cell lysis, opsinization and phagocytosis of free floating cells, antibody dependendent cell mediated cytotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are some diseases/conditions resulting from a type II reaction?

A

pemphigus foliaceous, autoimmune hemolytic anemia, myasthenia gravis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the target of pemphigus foliaceous?

A

skin cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What mechanism does pemphigus foliaceous use?

A

antibody binds to the cell adhesion molecule

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What does autoimmune hemolytic anemia target?

A

red blood cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the target of myasthenia gravis?

A

acetylcholine receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What type of antigen is associated with type III hypersensitivity?

A

a soluble antigen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What antibody is associated with type 3 hypersensitivity?

A

IgG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the mechanism used for cell destruction in type 3 hypersensitivity?

A

complement activation via the classical pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What cell type is usually involved with type 3 hypersensitivity?

A

neutrophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are mast cells activated by in type 3 hypersensitivity?

A

anaphylatoxins produced by complement fixation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What do the clinical signs of type 3 hypersensitivity result from?

A

complement, neutrophil, macrophage, and mast cell activation at the site of the immune complex deposition

17
Q

What are the type of reactions associated with type 3 hypersensitivity?

A

local and generalized reaction

18
Q

What is the local type 3 hypersensitivity reaction kalso nown as?

A

the arthus reaction

19
Q

How long does it to take for the arthus reaction to occur?

A

about 2-8 hours after exposure

20
Q

How does the arthus reaction work?

A

after the antigen is introduced into the tissue, antbody in circulation binds to it formin immune-complexes that stay localized and induce inflammation at the site of antigen introduction

21
Q

How does generalized type 3 hypersensitivity reactions work?

A

the antigen in antibody are in the circulation allowing the immune-complexes to circulate and get deposited at blood filtration points

22
Q

How long does it take for the generalized type 3 hypersensitivity reaction to work?

A

7-10 days upon first exposure and 1 -2 days upon second exposure

23
Q

What clinical signs are usually found at sites of immune complex deposition?

A

vasculitis, synovitis, nephritis, and neurological signs

24
Q

What are the differences in antibody between type I and type III hypersensitivity reactions?

A

type I is IgE, type III is IgG

25
Q

What is the difference in time between type I and III hypersensitivity reactions?

A

type I takes 10-15 minutes, type III takes 5-6 hours for initial response

26
Q

Neutrophils are associated with what type of hypersensitivity reaction?

A

type III

27
Q

Eosinophils are associated with what type of hypersensitivity reaction?

A

type I

28
Q

What Is an example of a systemic (generalized) type III hypersensitivity reaction?

A

serum sickness

29
Q

What is type 4 hypersensitivity also known as?

A

Delayed type hypersensitivity

30
Q

What antigen is associated with type 4 hypersensitivity?

A

T- cell (Th or CTL)

31
Q

What mediates type 4 hypersensitivity?

A

T cells, monocytes, and macrophages

32
Q

True or False: IgA is important in type 4 hypersensitivity.

A

False - it is not antibody mediated

33
Q

If an animal is not sensitized, how long does it take for a type 4 hypersensitivity to take in effect?

A

1-2 weeks

34
Q

In a sensitized animal, how long does it take for a type 4 hypersensitivity reaction to take an effect?

A

24-72 hours

35
Q

Why does it take 24-72 hours for the reaction to take place in sensitized animals?

A

It takes time for the memory t cells to interact with the antigen, and then takes about 24 hours after exposure for recruitment of macrophages

36
Q

What are some clinical manifestations associated with type 4 hypersensitivity?

A

induration, erythema, vesicles

37
Q

What does the TB test test for?

A

the presence of Th1 under the skin

38
Q

What does it mean if there is a hard lump 24-72 hours after being administered the TB antigen?

A

that there were th1 cells present meaning the patient either had the TB vaccine or they currently have TB

BMS 501 (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions