Two Phase System Emulsions Flashcards

1
Q

Homogenous preparation

A

Emulsion

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2
Q

Two face system in which one liquid is dispersed in the form of small globules throughout another liquid in which it is immiscible

A

Emulsion

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3
Q

What are the three components of an emulsion?

A

Disperse liquid — internal phase/ discontinuous phase

Dispersion medium — external phase/continuous phase

Intermediate Agent — emulsifying Agent/dispersing or stabilizing agent/emulsifier/intermediate liquid/surfactant

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4
Q

External phase

A

Dispersion medium

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5
Q

Discontinuous phase

A

Dispersion liquid

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6
Q

Dispersing or stabilizing agent

A

Intermediate agent

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7
Q

Composition of oil-in-water emulsion

A

External phase: water
Internal phase: oil
Continuous phase: water
Discontinuous phase: oil

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8
Q

Composition if an emulsifier

A

Hydrophilic head - water loving

Lipophilic tail - oil loving

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9
Q

2 Types of emulsifying Agent

A

Natural or synthetic

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10
Q

Natural emulsifying agent with animal origins

A

Gelatin
Egg yolk
Casein
Wolfat
Cholesterol

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11
Q

Natural emulsifying agent with vegetable origins

A

Chondrus
Acacia
Tragacanth

Pectin
Carrageenan

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12
Q

Synthetic emulsifying Agent

A

Finely divided solid
Colloid
Anionic
Catonic
Non-ionic
Amphoteric

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13
Q

Finely divided solid

A

Mg(OH)2
Al(OH)3
Magnesium trisilicate

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14
Q

Colloid

A

Kaolin
Bentonite Magma

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15
Q

Anionic

A

SLS — sodium lauryl sulfate

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16
Q

Cationic

A

Benzalkonium chloride

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17
Q

Non-ionic

A

PEG 400
Spans
Tween (polysorbate)

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18
Q

Amphoteric

A

Lecithin

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19
Q

Type of emulsion

A

Simple
Multiple
Microemulsion

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20
Q

Simple emulsion

A

O/W used internally
W/O

21
Q

Multiple emulsions

A

O/w/o
W/o/w

22
Q

Most stable of the three types of emulsion

Dispersed phase is in very small globules

100-1000A (1A=0.1nm)

A

Microemulsion

23
Q

Methods of preparation for emulsions

A

Wet or English
Dry or continental
Bottle or Forbes

24
Q

Primary nucleus is triturated in One Direction, creamy, sticky mixture with cracking sound

4:2:1 (O:W:EA) or (O:W:G)

A

Wet or English
Dry or Continental

25
Q

Volatile oil (3:2:1 = O:W:G) shaking vigorously

A

Bottle or Forbes

26
Q

Wet or English method

A

1:Gum/Emulsifying Agent
2:Water
4:Oil

Gum and water forms mucilage so better add the gum carefully to water

27
Q

Dry or continental method

A

1:Gum or Emulsifying Agent
4:Oil
2:Water

Add water all at once for this method

28
Q

Bottle or Forbes

A

1:Gum/Emulsifying Agent
3:Oil
2:Water

29
Q

Rough mortar and pestle is used for this method of preparation of emulsions

A

Dry or continental

30
Q

One part gum is triturated with two parts water to form a mucilage

Four parts oil is then added slowly, in portions, while triturating

A

English or wet gum method

31
Q

One part gum is levigated with four parts oil until powder is thoroughly wetted

Then two parts of water is added all at once

Continually triturated until primary emulsion formed is. creamy white and produces crackling sound as it is triturated

A

Continental or dry gum method

32
Q

Mortar and pestle with rough inner surface

A

Dry Wedgewood mortar and pestle

33
Q

The ratio between oil water and gum is 2:2:1 or 3:2:1

A

Bottle or Forbes

34
Q

Criteria for selecting an emulsifier

A

Compatible with other formulative agents

Should not interfere with the stability or efficacy of the therapeutic Agent

Stable and does not deteriorate in the preparation

Nontoxic with respect to its intended use

Should possess little odor or taste

35
Q

Problem: Temporary separation of the two phases

Solution: shake again

A

Creaming

36
Q

Problem: total separation of the 2 phases with coalescence

Solution: none (should be avoided at all costs)

A

Cracking

37
Q

Evaporation of water
O/W -> W/O

A

Phase inversion

38
Q

Change of one type of emulsion to another type due to an addition of an electrolyte or change in emulsifying agent or temperature.

A

Phase inversion

39
Q

To identify an emulsion — add a drop of water
Homogenous ->O/W

A

Drop dilution test

40
Q

Result of drop dilution test

A

O/W

41
Q

Oil soluble —> Sudan red —> W/O
Water soluble —> amaranth green/methylene blue —> O/W

A

Dye solubility test

42
Q

If the result of the dye solubility test is Sudan red, what is the type of emulsion?

A

W/O

43
Q

If the result of the dye solubility test is Amaranth green what is the type of emulsion identified?

A

O/W

44
Q

Electric conductivity test identifies?

A

O/W
Water conduct electricity

45
Q

What does fluorescent test identify?

A

W/O
Oil can absorb UV light

46
Q

Dispersed particles will come together, but does not fuse meaning that they will not form into a large globule

A

Flocculation

47
Q

Process in which two or more droplets merge together to form a single large droplet
It is an irreversible process

A

Coalescence

48
Q

Total separation of the two phases with coalescence

A

Cracking