Two component sensor regulators

Question 1

What are Two component sensor regulators?

Answer 1

signal transduction devices which allow the bacteria to sense different conditions

Question 2

What is meant by a pleiotropic regulator

Answer 2

A regulator with more than one effect

Question 3

What is the structure of a Two component sensor regulator?

Answer 3

A sensor in the membrane
A cytoplasmic transcriptional regulator

Question 4

What does phosphorylation of the regulatory protein lead to?

Answer 4

Change in transcription for some genes

Question 5

Describe one way in which two component sensor regulators can effect transcription

Answer 5

• Transcription site can be blocked by default, However will be unblocked when the regulator is phosphorylated

Question 6

What does PhoP and PhoQ regulate on bacteria?

Answer 6

Calcium and magnesium

Question 7

How does a mutation of PhoP or PhoQ lead to macrophage evasion by E.coli?

Answer 7

PhoP will become less negatively charged, Repelling the antimicrobial peptide

Question 8

How do PhoP use ca and mg?

Answer 8

During a repressed state the miners are on the surface, deactivating it.

Question 9

What effect do antimicrobials have on the membrane?

Answer 9

It will displace the irons, therefore turning on the Phop receptor

Question 10

What can you compare the mechanism of action for Phop and PhoQ to?

Answer 10

A simple on and off switch

Question 11

What does the Bvga-bvgs component sensors regulate?

Answer 11

Virulance factor production in whooping cough

Question 12

What activates the regulator for Bvga-Bvgs?

Answer 12

A temperature above 37c

Question 13

What deactivcates the regulator for Bvga-Bvgs?

Answer 13

Repressed by 25c

Question 14

What happens to the cell when Bvg is turned off?

Answer 14

Production of membrane proteins

Question 15

What happens to the cell when Bvg is turned on?

Answer 15

Production of adhesins and toxins