Two Compartment PK Flashcards
what compartments take longer to reach thiopental concentration
tissues with high affinity for a drug
what are the features of adipose tissue
poor perfusion and high partitioning
takes longer to achieve equilibrium
what does the two-compartment model assume
that distribution to the first compartment is faster than distribution to second compartment
what components are considered central compartments
plasma, extracellular fluid, highly perfused tissues
muscle is central compartment if not target organ
what components are considered peripheral compartments
deeper tissues with lower blood perfusion and large affinity for the drug
distribution takes some time
what are the two phases in IV bolus administration
distribution and terminal
what is the distribution phase in IV bolus
decline in plasma levels determined by distribution of drugs to tissues and elimination
what is the terminal phase in IV bolus
decline in plasma levels due to loss of drug from the body, re-distribution occurs
equilibrium plasma-tissues is achieved and the body acts as a single container, the drug conc in plasma and tissues may be different
what is the plasma profile for oral administration
biphasic curve if absorption phase is faster than distribution
how to calculate rate of change of drug in central compartment
rate of transfer back from tissue - rate of transfer to compartment - rate of elimination
how to calculate rate of change of drug in tissue compartment
rate of transfer from central compartment - rate of transfer back to central compartment
what is the equation fpr te concentration in the two compartment model
C1= Ae ^-at + Be ^bt
