Tutorials Flashcards

1
Q

What is nutritional anaemia?

A

Lack of B12, lack of folic acid, lack of iron

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2
Q

What is the treatment for nutritional aneamia?

A

Iron supplements, folic acid supplements
Diet change

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3
Q

What is pernicious anaemia?

A

VitB12 cannot be absorbed (even though it may be present)

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4
Q

What is the treatment for pernicious anaemia?

A

Injections of vitamin B12, called hydroxocobalamin

At first, you’ll have these injections every other day for 2 weeks or until your symptoms have started improving.

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5
Q

What is aplastic anaemia?

A

Abnormal precursors in the bone marrow

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6
Q

What is the treatment for aplastic?

A

Definitive treatment is about controlling or curing aplastic anaemia itself.

This can be done by either immuno-suppressive treatment (IST) or a stem cell transplant (SCT)

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7
Q

What is renal anaemia?

A

Kidney not working properly cannot sense or cannot produce EPO

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8
Q

What is the treatment for renal anaemia?

A

EPO injections

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9
Q

What is haemorrhage anaemia?

A

Huge amount of blood loss, not enough RBCs

Can be caused by heavy periods

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10
Q

What is the treatment for haemorrhage anaemia?

A

Stopping bleeding and iron supplements

If a large amount of blood is lost = can have transfusion

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11
Q

What is hemolytic anaemia?

A

RBC lyse and burst

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12
Q

What is the treatment for hemolytic anaemia?

A

Autoimmune hemolytic anaemia is treated with medicines such as steroids.

Steroids decrease the intensity of the immune system. Treatment must often continue for a long time until the immune system stops destroying blood cells.

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13
Q

What is malaria?

A

Parasites infect RBCs causing them to lyse

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14
Q

What is the treatment for malaria?

A

Must be treated quickly with anti-malarial medicines

Kills the parasite

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15
Q

What causes sickle cell disease?

A

Inherited

Beta-globulin group of Hb

Protein doesn’t fold properly, so RBCs are the wrong shape

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16
Q

What causes thalassemia?

A

In alpha thalassemia, mutations affect the alpha-globin genes, while in beta thalassemia, mutations affect the beta-globin genes.

The result is reduced or absent production of one or more globin chains, causing an abnormal hemoglobin structure.

17
Q

What is G6P deficiency?

A

G6P is important in protection against oxidative stress

No G6P = increase ROS so RBCs cannot respond to oxidative stress and lyse

18
Q

What is hereditary spherocytosis?

A

RBCs are round like sphere

They are more fragile

19
Q

What is the time for the prothrombin test?

A

12-14 seconds

20
Q

What is the time for activated partial thromboplastin time?

A

30-40 seconds

21
Q

What is PT for and how is it carried out?

A

Measures external clotting pathway

Take blood sample and add tissue factor III

Then time how long it takes

22
Q

What is APTT for and how is it carried out?

A

Measure intrinsic clotting pathway

Take blood sample

23
Q

What may cause external clotting pathway problems?

A

Warfarin

Vit K deficiency

Liver disease

DIC = disseminate intravascular coagulation

24
Q

What may cause internal clotting pathway problems?

A

Haemophilia

Von Williebrand disease

25
Q
A