Tumour suppressors, p53 and apoptosis Flashcards
1
Q
Which virus produces the viral oncogene E7 which inactivates the tumour suppressor RB?
A
HPV
2
Q
At which phase of the cell cycle does RB act as a gatekeeper?
A
G1
3
Q
RB regulates the activity of which family of proteins?
A
E2F
4
Q
What is the function of PTEN protein?
A
Phosphatase
5
Q
PTEN action is closely associated with inhibition of activity of which other protein?
A
AKT
6
Q
Which protein closely associates with TP53 and regulates its levels within a cell?
A
MDM2
7
Q
What is the function of TP53 protein?
A
transcription factor
8
Q
Which protein is a transcriptional target of TP53?
A
CDKN1A (p21)
