Cellular oncogenes, growth factors, receptors, signalling and cancer

Question 1

What does MYC protein act as?

Answer 1

Transcription factor

Question 2

Reciprocal translocation of the MYC gene and IgH promoter region is frequently observed in which cancer associated with EBV?

Answer 2

Burkitt’s lymphoma

Question 3

The BCR/ABL translocation is associated with the philadelphia chromosome. It is frequently observed in which cancer?

Answer 3

Chronic myeloid leukaemia (CML)

Question 4

HER2 in a complex with EGFR acts as a?

Answer 4

receptor tyrosine kinase

Question 5

Which cancer has the highest frequency of activating K-RAS point mutations?

Answer 5

Pancreatic cancer

Question 6

MYC protein associates with DNA in a complex that is?

Answer 6

Heterodimeric

Question 7

External signals can promote proliferation through upregulation of which cyclin?

Answer 7

Cyclin D1

Question 8

Herceptin is used to treat which type of cancer?

Answer 8

ERBB2 positive breast cancer

Question 9

During standard WNT, signalling the molecule beta-catenin associated with which transcription factor?

Answer 9

TCF