TUMOUR SUPPRESSORS Flashcards
1
Q
What is APC?
A
A tumour suppressor
2
Q
What is RB?
A
A tumour suppressor which is a cell cycle regulator
3
Q
Which virus produces the viral oncoprotein E7 which inactivated the tumour suppressor RB?
A
HPV
4
Q
At which phase of the cell cycle does RB act as a gatekeeper?
A
G1
5
Q
What family of proteins does RB regulate?
A
E2F
6
Q
What is the function of the PTEN gene?
A
Provides instructions for making an enzyme, acting as a tumour suppressorn
7
Q
What protein does PTEN inhibit?
A
AKT
8
Q
What is p53?
A
Tumour suppressor regulating cell division and DNA
9
Q
How is p53 activated?
A
Via phosphorylation in response to DNA damage
10
Q
What is the negative regulator of p53?
A
MDM2
11
Q
What is a critical process in the prevention of cancer?
A
Apoptosis
