CSNCER DIAGNOSIS/TREATMENTS

Question 1

What are the three cancer screenings available?

Answer 1

Bowel, cervical and breast

Question 2

What is sensitivity in terms of cancer screenings?

Answer 2

How accurate the screening test is in identifying disease in those who have the disease

Question 3

What is specificity in terms of cancer screenings?

Answer 3

How accurate the screening test is in correctly classifying non diseased people

Question 4

What does a cervical screening show?

Answer 4

HPV positive indicates possible cancer

Question 5

What does a bowel screening show?

Answer 5

FOT (change in blood colour) or FIT (detects blood in stool)

Question 6

What are the cytotoxic drugs used in cancer treatment?

Answer 6

Alkylating agents, antimetabolites, topoisomerase, tubular acting drugs

Question 7

What do alkylating agents do?

Answer 7

Cause direct DNA damage and block replication

Question 8

What do antimetabolites do?

Answer 8

Sabotage a cancers genetic material so it cannot replicate (purine, pyrimidine, folic acid)

Question 9

What do topoisomerase inhibitors do?

Answer 9

block enzyme action

Question 10

What do tubulin acting drugs do?

Answer 10

block chromatid separation

Question 11

What does advexin target?

Answer 11

gene therapy for p53

Question 12

CA125 tumour marker is associated with which cancer?

Answer 12

ovarian

Question 13

What is the name of internal radiation?

Answer 13

brachytherapy

Question 14

What regulates P53?

Answer 14

MDM2

Question 15

What is the role of Nutlin 3?

Answer 15

Inhibit P53 -MDM2 interaction

Question 16

What are telomeres?

Answer 16

Protein complexes at the end of chromosomes that are crucial for survival of cancer cells