Tumors of Cellular Migrants to Skin

Question 1

Presents in skin.
May evolve into generalized lyphoma.
Usually >40yrs.
Usually on trunk

Answer 1

Mycosis fungoides

Question 2

Three stages

Patch > plaque > nodule

Answer 2

Mycosis fungoides

Question 3

Multiple large nodules indicate systemic spread

Answer 3

Mycosis fungoides

Question 4

Include urticaria pigmentosa and systemic mastocytosis

Answer 4

Mastocytosis

Question 5

Usually children.
>50% of mastocytosis cases
Usually multiple mastocytomas - round/oval, red-brown papules and plaques. Pruritic. May blister. Appear shortly after birth

Answer 5

Urticaria Pigmentosa

Question 6

Usually adults.
10% of mastocytosis cases.
Lesions similar to urticaria pigmentosa PLUS multi-organ mast cell infiltration (BM, liver, spleen, LNs)

Answer 6

Systemic Mastocytosis

Question 7

Cutaneous T cell lymphoma

Answer 7

Mycosis fungoides

Question 8

Darier sign - wheal when skin lesion is rubbed

Dermatographism

Answer 8

Mastocytosis

Question 9

Pruritus and flushing triggered by certain foods, drugs, alcohol, temperature changes, etc. seen in systemic diseases of __________

Answer 9

mastocytosis

Question 10

Mastocytosis symptoms due to ___________ release, _______, and other ______ cell contents

Answer 10

histamine
heparin
mast

Question 11

Metachromatic granules within dendritic mast cells.
Monomorphous dermal infiltrate.
Fried egg cells.
Giemsa stain visualize mast cell granules.

Answer 11

Mastocytosis