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Exam 6 > McGuffin Skin/Epidermis > Flashcards

McGuffin Skin/Epidermis Flashcards

1
Q

Derived from mesoderm

A

dermis and hypodermis

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2
Q

Hypodermis also known as ________ layer

A

subcutaneous

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3
Q

Stratified epithelium. Cells flatten as they mature and approach surface. Have several layers with specialized functionality

A

Epidermis

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4
Q

Has rete ridges/processes/pegs

A

epidermis

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5
Q

Epithelial extensions that project into underlying connective tissue and mucous membranes of dermis

A

rete ridges

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6
Q

Only ___________ is thicker in thin skin, specifically____________

A

epidermis

stratum corneum

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7
Q

Thick skin only has _________ present

A

stratum lucidum

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8
Q

Has prominent epidermal and dermal ridges that form fingerprints

A

thick skin

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9
Q

Multiple sweat glands
No hair follices
Few melanocytes

A

Thick skin

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10
Q

Merkel cells, meissner and pacinian corpuscles in dermis and hypodermis

A

thick skin

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11
Q

Thin stratum corneum and no stratum lucidum

A

thin skin

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12
Q

Many hair follicles and melanocytes

Few sweat glands

A

thin skin

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13
Q

Sodium channel _______ is a degenerin over expressed that causes neurons to __________

A

BNC1

degenerate

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14
Q

Dendrites encapsulated in connective tissue

A

meissner corpuscles

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15
Q

Respond to slow vibration and texture

A

meissner corpuscle

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16
Q

Expanded dendritic endings.

Synapse with myelinated afferent axons of dorsal root ganglion cells.

A

Merkel cells

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17
Q

Found in basal layer of thick skin only, especially at fingertips and toes

A

Merkel cells

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18
Q

Have dense-core neurosecretory vesicles in their basal cytoplasm

A

merkel cells

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19
Q

Respond to sustained pressure and touch

A

merkel cells

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20
Q

Unmyelinated dendritic endings of sensory nerve fibers.

A

Pacinian corpuscle

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21
Q

Encapsulated by concentric lamellae of connective tissue.

Appears as an onion

A

Pacinian corpuscle

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22
Q

Respond to deep pressure and fast vibration

A

Pacinian corpuscle

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23
Q

Enlarged dendritic endings with elongated capsules

A

Ruffini endings

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24
Q

Respond to sustained pressure

A

ruffini endings

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25
Q

Located around hair follicles. Detect pain and temperature

A

Unmyelinated dendrites of sensory nerve fibers

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26
Q

Outermost layer where cells are fully differentiated

A

stratum corneum (cornified layer)

27
Q

Dead keratinocytes appear as flattened keratinized flakes or squames of keratin. Constantly flake off (desquamation) with abrasion. Provides wearing surface for skin

A

Stratum corneum

28
Q

Thin layer only present in thick skin

A

lucidum

29
Q

Continuation of differentiation of keratinocytes from stratum granulosum.

A

lucidum

30
Q

Keratinocytes are flat, dead cells with no organelles or nucleus. Few to no melanin granules, completely filled with keratin and are weakly stainied

A

lucidum

31
Q

Also known as clear layer

A

lucidum

32
Q

Layer in which keratinocytes become flattened.

A

Stratum Granulosum

33
Q

Synthesized from bundles of keratin cross linked with filaggrin

A

Keratohyalin granules

34
Q

Attaches keratin intermediate filaments to desmosomes to support cytoskeleton and promote attachment to adjacent cells providing mechanical strength to epidermis

A

Filaggrin

35
Q

Darkly basophilic granular appearance

A

granulosum

36
Q

Programmed destruction of nucleus and organelles of keratinocytes in this layer

A

granulosum

37
Q

Lamellar bodies release lipid into intercellular space, which makes cells waterproof

A

granulosum

38
Q

Consists of several layers of squamous epithelial cells known as keratinocytes

A

Spinosum

39
Q

Have spiny apperance due to spike-like cytoplasmic projections that form intercellular bridges between cells

A

Keratinocytes

40
Q

Keratinocytes in this layer held together by desmosomes

A

spinosum

41
Q

Also known as macula adherens

A

desmosomes

42
Q

Immune cells derived from monocytes

A

langerhans cells

43
Q

Have cytoplasmic processes similar to dendrites of neurons that extend between keratinocytes. Function as antigen presenting cells

A

Langerhans cells

44
Q

Found in all layers of epidermis of thick and thin skin, but mostly in spinosum

A

langerhans cells

45
Q

Synthesize keratin and lamellar bodies

A

keratinocytes

46
Q

keratinocytes take up

A

melanin granules

47
Q

Protective protein made by keratinocytes.

Made up in part of intermediate filaments of cytoskeleton

A

keratin

48
Q

Lipid filled, non-membrane bound structures synthesized by kerationcytes and stacked as lamellae

A

Lamellar bodies

49
Q

Synthesized by melanocytes and taken up by keratinocytes

A

melanin granules

50
Q

Single layer of cuboidal cells attached to basement membrane by hemidesmosomes

A

Basale

51
Q

Attach one cell to extracellular matrix

A

hemidesmosomes

52
Q

Layer contains keratinocyte stem cells and melanocytes

A

basale

53
Q

Melanocytes are derived from __________

A

neural crest cells

54
Q

Produce melanin

A

melanocytes

55
Q

Have slender cytoplasmic processes insinuated between nearby keratinocytes

A

melanocytes

56
Q

Synthesized from tyrosine and DOPA

A

melanin

57
Q

Transferred from melanin containing tips of melanocyte cytoplasmic processes to keratinocyte in _____________

A

membrane bound granules

58
Q

In keratinocyte, melanin located adjacent to _________

A

nucleus

59
Q

Provides protection to DNA by absorbing and scattering UV radiation

A

melanin

60
Q

Red yellow form of melanin

A

pheo

61
Q

brown black form of melanin

A

eu

62
Q

Absence of melanocytes due to autoimmune destruction

A

vitiligo

63
Q

Derived from ectoderm

A

Epidermis

Exam 6 (11 decks)

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