McGuffin Skin/Epidermis

Question 1

Derived from mesoderm

Answer 1

dermis and hypodermis

Question 2

Hypodermis also known as ________ layer

Answer 2

subcutaneous

Question 3

Stratified epithelium. Cells flatten as they mature and approach surface. Have several layers with specialized functionality

Answer 3

Epidermis

Question 4

Has rete ridges/processes/pegs

Answer 4

epidermis

Question 5

Epithelial extensions that project into underlying connective tissue and mucous membranes of dermis

Answer 5

rete ridges

Question 6

Only ___________ is thicker in thin skin, specifically____________

Answer 6

epidermis

stratum corneum

Question 7

Thick skin only has _________ present

Answer 7

stratum lucidum

Question 8

Has prominent epidermal and dermal ridges that form fingerprints

Answer 8

thick skin

Question 9

Multiple sweat glands
No hair follices
Few melanocytes

Answer 9

Thick skin

Question 10

Merkel cells, meissner and pacinian corpuscles in dermis and hypodermis

Answer 10

thick skin

Question 11

Thin stratum corneum and no stratum lucidum

Answer 11

thin skin

Question 12

Many hair follicles and melanocytes

Few sweat glands

Answer 12

thin skin

Question 13

Sodium channel _______ is a degenerin over expressed that causes neurons to __________

Answer 13

BNC1

degenerate

Question 14

Dendrites encapsulated in connective tissue

Answer 14

meissner corpuscles

Question 15

Respond to slow vibration and texture

Answer 15

meissner corpuscle

Question 16

Expanded dendritic endings.

Synapse with myelinated afferent axons of dorsal root ganglion cells.

Answer 16

Merkel cells

Question 17

Found in basal layer of thick skin only, especially at fingertips and toes

Answer 17

Merkel cells

Question 18

Have dense-core neurosecretory vesicles in their basal cytoplasm

Answer 18

merkel cells

Question 19

Respond to sustained pressure and touch

Answer 19

merkel cells

Question 20

Unmyelinated dendritic endings of sensory nerve fibers.

Answer 20

Pacinian corpuscle

Question 21

Encapsulated by concentric lamellae of connective tissue.

Appears as an onion

Answer 21

Pacinian corpuscle

Question 22

Respond to deep pressure and fast vibration

Answer 22

Pacinian corpuscle

Question 23

Enlarged dendritic endings with elongated capsules

Answer 23

Ruffini endings

Question 24

Respond to sustained pressure

Answer 24

ruffini endings

Question 25

Located around hair follicles. Detect pain and temperature

Answer 25

Unmyelinated dendrites of sensory nerve fibers

Question 26

Outermost layer where cells are fully differentiated

Answer 26

stratum corneum (cornified layer)

Question 27

Dead keratinocytes appear as flattened keratinized flakes or squames of keratin. Constantly flake off (desquamation) with abrasion. Provides wearing surface for skin

Answer 27

Stratum corneum

Question 28

Thin layer only present in thick skin

Answer 28

lucidum

Question 29

Continuation of differentiation of keratinocytes from stratum granulosum.

Answer 29

lucidum

Question 30

Keratinocytes are flat, dead cells with no organelles or nucleus. Few to no melanin granules, completely filled with keratin and are weakly stainied

Answer 30

lucidum

Question 31

Also known as clear layer

Answer 31

lucidum

Question 32

Layer in which keratinocytes become flattened.

Answer 32

Stratum Granulosum

Question 33

Synthesized from bundles of keratin cross linked with filaggrin

Answer 33

Keratohyalin granules

Question 34

Attaches keratin intermediate filaments to desmosomes to support cytoskeleton and promote attachment to adjacent cells providing mechanical strength to epidermis

Answer 34

Filaggrin

Question 35

Darkly basophilic granular appearance

Answer 35

granulosum

Question 36

Programmed destruction of nucleus and organelles of keratinocytes in this layer

Answer 36

granulosum

Question 37

Lamellar bodies release lipid into intercellular space, which makes cells waterproof

Answer 37

granulosum

Question 38

Consists of several layers of squamous epithelial cells known as keratinocytes

Answer 38

Spinosum

Question 39

Have spiny apperance due to spike-like cytoplasmic projections that form intercellular bridges between cells

Answer 39

Keratinocytes

Question 40

Keratinocytes in this layer held together by desmosomes

Answer 40

spinosum

Question 41

Also known as macula adherens

Answer 41

desmosomes

Question 42

Immune cells derived from monocytes

Answer 42

langerhans cells

Question 43

Have cytoplasmic processes similar to dendrites of neurons that extend between keratinocytes. Function as antigen presenting cells

Answer 43

Langerhans cells

Question 44

Found in all layers of epidermis of thick and thin skin, but mostly in spinosum

Answer 44

langerhans cells

Question 45

Synthesize keratin and lamellar bodies

Answer 45

keratinocytes

Question 46

keratinocytes take up

Answer 46

melanin granules

Question 47

Protective protein made by keratinocytes. | Made up in part of intermediate filaments of cytoskeleton

Answer 47

keratin

Question 48

Lipid filled, non-membrane bound structures synthesized by kerationcytes and stacked as lamellae

Answer 48

Lamellar bodies

Question 49

Synthesized by melanocytes and taken up by keratinocytes

Answer 49

melanin granules

Question 50

Single layer of cuboidal cells attached to basement membrane by hemidesmosomes

Answer 50

Basale

Question 51

Attach one cell to extracellular matrix

Answer 51

hemidesmosomes

Question 52

Layer contains keratinocyte stem cells and melanocytes

Answer 52

basale

Question 53

Melanocytes are derived from __________

Answer 53

neural crest cells

Question 54

Produce melanin

Answer 54

melanocytes

Question 55

Have slender cytoplasmic processes insinuated between nearby keratinocytes

Answer 55

melanocytes

Question 56

Synthesized from tyrosine and DOPA

Answer 56

melanin

Question 57

Transferred from melanin containing tips of melanocyte cytoplasmic processes to keratinocyte in _____________

Answer 57

membrane bound granules

Question 58

In keratinocyte, melanin located adjacent to _________

Answer 58

nucleus

Question 59

Provides protection to DNA by absorbing and scattering UV radiation

Answer 59

melanin

Question 60

Red yellow form of melanin

Answer 60

pheo

Question 61

brown black form of melanin

Answer 61

eu

Question 62

Absence of melanocytes due to autoimmune destruction

Answer 62

vitiligo

Question 63

Derived from ectoderm

Answer 63

Epidermis