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Exam 6 > Rickettsia > Flashcards

Rickettsia Flashcards

1
Q

Obligate intracellular. Replicate in cytoplasm of cells. Difficult to see in tissues - need giemsa stain

A

Rickettsia

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2
Q

Causes rocky mountain spotted fever

A

Rickettsia rickettsii

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3
Q

Has outer membrane protein A

A

rickettsia rickettsii

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4
Q

Allows adherence to endothelial cells

A

outer membrane protein A

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5
Q

Replication in cytoplasm and nucleus results in vasculitis

A

Rickettsia rickettsii

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6
Q

Intracellular growth protects bacteria from clearance

A

rickettsia rickettsii

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7
Q

Most common rickettsia causing human disease in USA

A

rickettsia rickettsii

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8
Q

90% of infections from april-september

A

rickettsia rickettsii

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9
Q

Vectors are ticks (lxodeae family)

Dermacentor adersoni and dermacentor variabilis

A

rickettsia rickettsii

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10
Q

Dermacentor andersoni

A

Wood tick (rocky mountain states) of rickettsia rickettsii

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11
Q

Dermacentor variabilis

A

Dog tick (SE US) of rickettsia rickettsii

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12
Q

Occurs in Arkansas, Delaware, Missouri, North Carolina, Oklahoma, and Tennessee

A

rickettsia rickettsii

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13
Q

Tick reservoir via transovarian transmission

A

Rickettsia rickettsii

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14
Q

6-10 hours after tick bite dormant, avirulent bacteria are activated by warm blood meal. Translocation of bacteria from salivary glands to bloodstream

A

Rickettsia rickettsii

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15
Q

Bacteria incubates 2-14 days. Centripetal rash on palms and soles of feet. Respiratory failure, encephalitis, renal failure, myocarditis
Fatal in 20% of untreated cases

A

RMSF

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16
Q

Erythematous

macular > papular > petechial

A

RMSF

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17
Q

Thrombocytopenia, coagulopathy, anemia, normal WBC count, hyponatremia, transaminitis

A

RMSF

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18
Q

National notifiable disease

A

RMSF

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19
Q

In acute phase RMSF organism best detected by _______ and ________

A

PCR

immunohistochemistry

20
Q

For RMSF paired _________ and _______ samples are essential for confirmation

A

acute

convalescent

21
Q

Fourfold increase in _______ for rickettsii between acute and convalescent serum comparisons

A

IgG

22
Q

Causes rickettsialpox

A

Rickettsia akari

23
Q

Transmitted by infected mites. Rodents (common house mouse) is reservoir. Humans accidental hosts when bitten by infected mites

A

Rickettsia akari

24
Q

Rickettsialpox has ____________ presentation

A

biphasic

25
Q

Gram - bacilli. Minimal peptidoglycan layer. LPS weak endotoxic activity. No beta-lactam treatment

A

Rickettsia

26
Q

First phase - 1 wk after bite. Papule > ulcer > eschar at bite site.
Incubation 7-24 days, then systemic spread.
Second phase: High fever, severe headache, photophobia, papulo-vesicular rash, pox-like progression (vesicles crust over)

Milder course than RMSF

A

Rickettsialpox

27
Q

Must be differentiated from anthrax

A

rickettsialpox

28
Q

Anthrax patients only have ______

A

eschar

29
Q

Can be either epidemic or sporadic.
Epidemic - louse born typhus
USA sporadic - fleas from flying squirrels

A

Rickettsia prowazekii

30
Q

Humans main reservoir.
Transmitted by pediculus humanus (body louse)
Rare in USA - seen in disasters, war, famine

A

Epidemic (louse-borne) typhus

31
Q

During blood meal, louse defecates highly infective feces at feeding site. Bacteria present in louse feces introduced into bite site. Lice feces may remain infectious for as long as ____ days > can have human to human transmission via clothes

A

Rickettsia prowazekii

100

32
Q

Can have 2 syndromes - acute, severe vasculitis form or recrudescent form

A

Rickettsia prowazekii

33
Q

7-14 days after contact with infected lice. Fever, CNS sxs.

Centrifugal maculopapular rash

A

Acute, potentially severe vasculitis of Rickettsia prowazekii

34
Q

10-50 yrs after primary infection.

Milder form. Rash, flu-like sxs. Elderly pts (WWII refugees)

A

Recrudescent form (Brill-Zinsser disease) of Rickettsia prowazekii

35
Q

Diagnose by serology MIF test

A

Rickettsia prowazekii

36
Q

American Boutonneuse fever/Tidewater spotted fever

A

Rickettsia parkeri

37
Q

Recently described (index case 2002). Mainly southern USA (in VA).

A

Rickettsia parkeri

38
Q

Vector is amblyomma maculatum (gulf coast tick).

A

Rickettsia parkeri

39
Q

Several eschars and rash.
Low mortality.
Serology, PCR, culture from skin biopsy

A

Rickettsia parkeri

40
Q

Perivascular mononuclear inflammatory cell infiltrates and edema of adjacent superficial dermis and intact epidermis

A

Rickettsia parkeri

41
Q

Endemic (murine) typhus.

Worldwide. More in warm, humid areas

A

Rickettsia typhi

42
Q

Reservoir is rodents.

Main vector is xenopsylla cheopis (rat flea). Also cat flea in USA

A

Rickettsia typhi

43
Q

Inoculated by infective flea feces in bite wounds

A

Rickettsia typhi

44
Q

Mild and non-specific symptoms. Variable presentation of rash.
Serology by IFA

A

Rickettsia typhi

45
Q

With ________ diseases, early reliable diagnosis is not possible. Clinical presentation and epidemiological setting is key

A

rickettsial

Exam 6 (11 decks)

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