Tumors

Question 1

Glioblastoma (IV) genetic mutations?

Answer 1

• CDKN2A deletion
• Amplification of EGFR or PDGFR
• TP53

Question 2

Primary GBM, who is it seen in and what are mutations?

Answer 2

• Older patient with no precurosr lesion
• IDH wild type
• gains in chromosome 7 loss in chromoosome 10 TERT and EGFR

Question 3

Prognosis of glioblastoma IDH mutant?

Answer 3

• IDH mutatnts are aggressive but have a better prognosis with avg survival of 2-3 yrs

Question 4

Secondary GBM who is it seen in, mutations, and prognosis?

Answer 4

• Younger patients with a preceeding lower grade lesion (TP53)
• idh1 (better prognosis than wild type)

Question 5

What varient of medulloblastoma (IV) is described with large irregular vesicular nuclei, priminent nucleoli with “cell wrapping”, and a high mitotic/apoptotic rate?

Answer 5

Large cell/Anaplastic

Question 6

Histology and gross appearance of Medulloblastoma?

Answer 6

• Densely cellular
• Sheets of anaplastic cells
• Abundant mitoses

Gross:

• well circumscribed
• gray friable
• may involve leptomeninges

Question 7

Which can be dissected off, schwannoma or neurofibroma?

Answer 7

Schwannoma it sits on the nerve and neurofibroma is intergrated in the nerve

Question 8

What mutation is with Schwannoma? What stain?

Answer 8

• NF2, loss of Merlin
• Sporadic associated with NF2 on CHR 22
• stains with S100

Question 9

Where are schwannomas located

Answer 9

Cerebellar pontine angle

Question 10

What are the problems seen with acoustic neuromas?

Answer 10

• CN VIII, tinnitus and hearing loss

Question 11

What is described as eosinophilic spindle cells arranged in intersecting fascicles?

Answer 11

Antoni A (Dense)

Question 12

What are Verocay bodies?

Answer 12

• Palisading nuclei around nuclear free zones
• seen in schwannomas

Question 13

What is Antoni B (loose)?

Answer 13

Hypocellular myxoid ECM in a microcyst formation

Seen in Schwannomas