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Pathology > Tumor suppressor genes and associated cancers > Flashcards

Tumor suppressor genes and associated cancers Flashcards

1
Q

Rb

A

RBO Speedwagon (Retinoblastoma, osteosarcoma) —— inhibits E2F; blocks G1-> S phase

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2
Q

p53

A

Most cancers, Li-Fraumeni syndrome —— Transcription factor for p21 -> promotes apoptosis at G1-> S phase via upregulation of pro-apoptotic genes (ie BAX) when DNA damage/ mutations present

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3
Q

BRCA1 & BRCA2

A

Breast and ovarian cancer —– DNA repair protein

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4
Q

p16

A

Melanoma

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5
Q

APC

A

Colorectal cancer (FAP, turcot syndrome, garnder syndrome)

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6
Q

WT1

A

Wilm’s tumor (nephroblastoma)

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7
Q

NF1

A

NeuroFibromatosis type 1 ——— RAS GTPase activating protein (RAS GAP)

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8
Q

NF2

A

NeuroFibromatosis type 2 ——– Merlin (Schwannomin) protein

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9
Q

DPC4

A

Pancreatic cancer (DPC -> Deleted in Pancreatic Cancer)

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10
Q

DCC

A

Colon cancer (Deleted in Colon Cancer)

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Pathology (8 decks)

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