Oncogenes and associated cancers

Question 1

abl

Answer 1

CML- non-receptor tyrosine kinase

Question 2

c-myc

Answer 2

Burkitt’s lymphoma- transcription factor

Question 3

bcl-2

Answer 3

Follicular and undifferentiated lymphomas- Anti-apoptotic

Question 4

HER2/ neru (c-erbB2)

Answer 4

Breast, ovarian, gastric carcinomas- tyrosine kinase

Question 5

K-ras

Answer 5

Colon, pancreas, lung cancers (Kolon, panKreatic)- GTPase

Question 6

H-ras

Answer 6

Bladder and kidney tumors (Hematuria)- GTPase

Question 7

N-ras

Answer 7

Melanomas, hematological malignancies- GTPase

Question 8

L-myc

Answer 8

Lung (small cell lung cancer)- transcription factor

Question 9

N-myc

Answer 9

Neuroblastoma (adrenal gland)- transcription factor

Question 10

ret

Answer 10

MEN 2a and 2b (medullary thyroid cancer) and papillary thyroid cancer- tyrosine kinase

Question 11

c-kit

Answer 11

GIST (gastrointestinal stromal tumor)- cytokine receptor

Question 12

BRAF

Answer 12

Melanoma