Paraneoplastic syndromes

Question 1

**ACTH-> Cushings

Answer 1

Small cell lung cancer

Question 2

**ADH -> SIADH

Answer 2

Small cell lung cancer and CNS disorders (incl CNS neoplasms)

Question 3

**Erythopoietin -> polycythemia

Answer 3

1. RCC
2. Hemagioblastoma
3. HCC
4. Pheochromocytoma

Question 4

Calcitriol (active vit D) -> Hypercalcemia

Answer 4

Hodgkins and some non-hodgkins lymphomas

Question 5

PTHrP -> hypercalcemia

Answer 5

Squamous cell lung carcinoma and RCC; breast cancer and multiple myeloma have local osteolytic factors that eat bone and cause hypercalcemia

Question 6

Ab’s against presynaptic Ca++ channels -> muscle weakness

Answer 6

Small cell lung carcinoma (Lambert-Eaton syndrome)