Tumor Suppressor Genes Flashcards
1
Q
APC
A
-colorectal cancer
2
Q
BRCA1 / BRCA2
A
- breast and ovarian cancer
- DNA repair problem
3
Q
DCC
A
- colon cancer
- Deleted in Colon Cancer
4
Q
DPC4 / SMAD4
A
- pancreatic cancer
- Deleted in Pancreatic Cancer
5
Q
MEN1
A
- MEN1
- Menin
- 3P’s: Pituitary, Parathyroid, Pancreas
6
Q
NF1
A
- NF1
- Ras GTPase activating protein
7
Q
NF2
A
-NF2
Merlin
8
Q
p16
A
- Melanoma
- cyclin dependent kinase inhibitor 2A
9
Q
p53
A
- pretty much all cancers
- Li Fraumeni Syndrome
- transcription factor that blocks G1-S
10
Q
Rb
A
- Retinoblastoma, osteosarcoma
- Inhibits E2F, blocks G1-S phase
11
Q
PTEN
A
breast, prostate, endometrial cancer
12
Q
TSC1
A
- Tuberous sclerosis
- Hamartin protein
13
Q
TSC2
A
- Tuberous sclerosis
- tuberin protein
14
Q
VHL
A
-Von Hippel-Lindau disease, renal cell carcinoma
15
Q
WT1 / WT2
A
-Wilms Tumor, nephroblastoma
