Cytokines Flashcards
1
Q
IL-1
A
- fever and acute inflammation
- secreted by macrophages
2
Q
IL-2
A
- stimulates T cells and NK cells
- secreted by T cells
- receptor is CD25
3
Q
IL-3
A
- supports bone growth and stem cells
- secreted by T cells
4
Q
IL-4
A
- starts B cell differentiation
- class switch to IgE
- secreted by Th2
5
Q
IL-5
A
- maintains B cell differentiation
- class switch to IgA
- growth and differentiation of eosinophils
- secreted by Th2
6
Q
IL-6
A
- fever
- acute phase proteins
- secreted by macrophages
7
Q
IL-8
A
- neurtophil chemo-attractant
- secreted by macrophages
8
Q
IL-10
A
- attenuates the immune response
- inhibits activated macrophages and dendritic cells
- secreted by Th2
9
Q
IL-12
A
- differentiation of T cells into Th1
- activates NK cells
- released by macrophages
10
Q
TNF-a
A
- activates endothelium and permeability
- WBC recruitment
- mediates septic shock
- released by macrophages
11
Q
INF-y
A
- stimulates macrophages to kill pathogens
- increases MHC expression
- activates NK cells
- secreted by Th1 cells
