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Step 1 Basic Science > Oncogenes > Flashcards

Oncogenes Flashcards

1
Q

BCR-ABL

A
  • Tyrosine Kinase
  • t(9:22)
  • CML, ALL
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2
Q

BCL-2

A
  • removal of apoptosis block
  • Lymphomas
  • t(14:18)
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3
Q

BRAF

A
  • Serine/ threonine kinase

- Melanoma, Non-hodgkins

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4
Q

c-kit

A
  • cytokine receptor

- Gastrointestinal Stromal tumor

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5
Q

c-myc

A
  • transcription factor

- Burkitt lymphoma

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6
Q

HER2/neu (c-erbB2)

A
  • tyrosine kinase

- Breast, ovarian, gastric carcinomas

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7
Q

L-myc

A
  • transcription factor

- Lung tumor

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8
Q

N-myc

A
  • transcription factor

- Neuroblastoma

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9
Q

RAS

A
  • GTPase

- carcinoma, melanoma, lymphoma

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10
Q

RET

A
  • tyrosine kinase
  • MEN 2A: Parathyroids and Pheochromocytoma
  • MEN 2B: Pheochromocytoma
  • medullary thyroid
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11
Q

JAK2

A

-P.Vera, leukemia, myeloproliferative disorders

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Step 1 Basic Science (10 decks)

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