Tumor-immunology

Question 1

Adoptive T cell therapy

Answer 1

Isolation of T cells
Expansion
Transfer back to patients

Question 2

Two types

Answer 2

TIL
Gene engineered T cell therapy

Question 3

Gene engineered T cell therapy

Answer 3

Blood

Question 4

Gene engineered T cell therapy

Answer 4

CAR
TCR

Question 5

Properties receptors

Question 6

Main reason gene engineered

Answer 6

To make more specific –> use receptors for that

Question 7

More affinity for CAR, why? –> voordelen CAR: 3 min op opname

Question 8

availability of … targets is less for solid cancers 4 min ofzo

Question 9

Main challenges of T cell therapy (2)

Answer 9

1. Expand number of targets
2. Increase longevity of T cells

Question 10

Requirements for good targets

Answer 10

Not in healthy tissue
Multiple tumor types
Shared among patients
Immunogenic
Related to oncogenesis

Question 11

Typical targets

Answer 11

1. Oncoviral antigens
2. Neoantigens
3. Differentiation antigens
4. Over-expressed antigens
5. Cancer germline antigens

Question 12

Oncoviral antigens

Answer 12

1. EBV
2. HPV

Question 13

Differentiation antigens

Answer 13

Gp100

Question 14

Cancer germline antigens

Answer 14

1. NY-ESO1
2. Testis
3. Ovary
4. Placenta