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IS LEC MIDTERMS > Tumor Immunology > Flashcards

Tumor Immunology Flashcards

1
Q

an abnormal cell mass

A

tumor

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2
Q

2 types of tumor

A

benign and malignant

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3
Q

cancer is what type of tumor?

A

malignant

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4
Q

caused by mutations in protooncogenes and tumor-suppressor genes

A

cancer

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5
Q

cancer is a mutation caused by?

A

protooncogenes and tumor-suppressor genes

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6
Q

it is an uncontrolled cell division and other characteristics

A

cancer

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7
Q

patrols the body for cancer cells and destroys them before they become clinically evident?

A

Immunosurveillance

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8
Q

NK cells and macrophages

A

innate defenses

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9
Q

CTLs, dendritic cells, cytokines, antibodies

A

adaptive defenses

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10
Q

characteristics of cancer cells?

A
  • sustained proliferation
  • resist death
  • induce angiogenesis
  • immortality
  • invasion and metastasis
  • avoid suppressors of cell growth
  • altered metabolism
  • evasion of immune defenses
  • genomic instability
  • accelerated growth in the presence of inflammation
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11
Q

unique to the tumor and is coded by mutated protooncogenes or tumor-suppressor genes

A

Tumor-Specific Antigens (TSAs)

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12
Q

expressed in tumor cells and normal cells and is share tumor-specific antigens, differentiation antigens and overexpressed antigens

A

Tumor-Associated Antigens (TAAs)

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13
Q

on many tumor but not most normal tissues

A

share tumor-specific antigens

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14
Q

on immature cells of a particular lineage

A

differentiation antigens

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15
Q

found in higher levels on malignant cells

A

overexpressed antigens

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16
Q

elevated level of tumor markers indicates?

A

tumor mass

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17
Q

concentration in serum depends on?

A

amount of tumor proliferation and tumor size

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18
Q

to identify cancer in asymptomatic people?

A

population screening

19
Q

may detect cancer at an early stage but can get false pos or false neg results

A

population screening

20
Q

identifies cancer in a particular px

A

diagnosis

21
Q

predicts clinical outcome and aids in selection of therapy

A

patient prognosis

22
Q

decreasing levels of tumor markers indicate?

A

effective treatment

23
Q

increasing levels of tumor markers indicate?

A

ineffective treatment or tumor recurrence

24
Q

clinical uses of tumor markers

A
  • monitoring response of cancer patient to therapy
  • population screening
  • diagnosis
  • patient prognosis
25
Q

tumor marker AFP, what are its uses?

A

SDPM

26
Q

tumor marker CA 125 what are its uses?

A

SDPM

27
Q

tumor marker PSA what are its uses?

A

SDPM

28
Q

tumor marker CA19-9 what are its uses?

A

DPM

29
Q

tumor marker hCG what are its uses?

A

DPM

30
Q

tumor marker CEA what are its uses?

A

PM

31
Q

tumor marker AFP, what cancer is it?

A

liver

32
Q

tumor marker CA 125, what cancer is it?

A

ovarian

33
Q

tumor marker CA 19-9, what cancer is it?

A

pancreatic

34
Q

tumor marker CEA, what cancer is it?

A

colorectal and breast

35
Q

tumor marker hCG, what cancer is it?

A

testicular and trophoblastic

36
Q

tumor marker PSA, what cancer is it?

A

prostate

37
Q

uses labeled Abs to detect tumor antigens in tissue biopsies

A

immunohistochemistry

38
Q

measure levels of circulating tumor markers

A

immunoassays

39
Q

detect genetic mutations associated with cancer

A

molecular methods

40
Q

detects protein profile of a tumor population

A

proteomics

41
Q

sensitive and automated

A

immunoassays for serum tumor markers

42
Q

cross reactivity can produce ? results in immunoassays for serum tumor markers

A

false pos

43
Q

antigen excess can produce ? in immunoassays for serum tumor markers

A

false decrease

IS LEC MIDTERMS (7 decks)

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