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renal > Tubular processing of the glomerular filtrate. Proximal tubular reabsorption > Flashcards

Tubular processing of the glomerular filtrate. Proximal tubular reabsorption Flashcards

1
Q

filtration - process

A
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2
Q

reabsorption - location

A

RENAL TUBULES
PCT
loop of henle
DCT
collecting duct

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3
Q

proximal convoluted tubule - 1

A

sodium
- active transport from tubular cells into blood
- na/k-ATPase pump on basolateral membrane

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4
Q

proximal convoluted tubule - 2

A

water
- passively by osmosis due to high osmolarity in interstitial space
- aquaporins channels

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5
Q

proximal convoluted tubule - 3

A

nutrients = glucose/ amino acids
- active transport

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6
Q

proximal convoluted tubule - 4

A

electrolytes = cl-/ hco3-

  • passively reabsorbed
  • to help acid-base balance in body
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7
Q

descending limb - 1

A
  • highly permeable to water
  • impermeable to solutes na+/k+/cl-
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8
Q

descending limb - 2

A

when filtrate moves through descending limb, water gets reabsorbed into surrounding hypertonic interstitial fluid of medulla

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9
Q

descending limb - 3

A

filtrate gets more concentrated as it moves through medulla

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10
Q

ascending limb - 1

A

thick ascending limb

  • impermeable to water
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11
Q

ascending limb - 2

A

thick ascending limb

  • moves solutes by secondary active transport
  • by sodium-potassium-chloride cotransporter from filtrate into TAL
  • na/k ATPase pump takes sodium into interstitium forming a concentration gradient for sodium reabsorption
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12
Q

ascending limb - 3

A

filtrate gets diluted as nacl gets removed without water coming out

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13
Q

distal convoluted tubule - 1

A

sodium

  • sodium reabsorbed by na+/cl- symporter + na/k ATPase pump
  • enhanced by aldosterone
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14
Q

distal convoluted tubule - 2

A

potassium

secreted into filtrate in exchange for sodium

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15
Q

distal convoluted tubule - 3

A

calcium

  • calcium reabsorbed in exchange for sodium by sodium/ calcium exchanger _ calcium channels
  • under regulation of PTH
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16
Q

distal convoluted tubule - 4

A

water

  • impermeable to water
  • ADH can help water to be reabsorbed
17
Q

distal convoluted tubule - 5

A

ELECTROLYTES

acid-base pH balance by secreting H+ into filtrate / reabsorbs HCO3-

18
Q

collecting duct - 1

A

sodium

  • reabsorbed into collecting duct needed into body for blood volume/ pressure
  • enhanced by aldosterone as it activated sodium channels
19
Q

collecting duct - 2

A

potassium

  • secreted into collecting duct needed for cell function
  • enhanced by aldosterone
20
Q

collecting duct - 3

A

water

  • collecting duct is highly permeable to water
  • enhanced by ADH
21
Q

secretion - 1

A
  • h+ for acid base balance
22
Q

secretion - 2

A

creatinine/ urate/ drugs for excretion

renal (14 decks)

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