Summary of tubular reabsorption and secretion of glucose, peptides, urea, Flashcards

1
Q

glucose - reabsorption

A

all glucose is reabsorbed by sodium-glucose cotransporters in the PCT

then glucose taken into the blood by GLUT transporters

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2
Q

glucose - secretion

A

under normal conditions, glucose is not secreted in the tubules

but under uncontrolled diabetes, glucose enters urine

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3
Q

peptides - reabsorption

A

most small peptides are reabsorbed in the PCT by endocytosis

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4
Q

peptides - secretion

A

normally, only very small traces of peptides in urine

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5
Q

urea - reabsorption

A

urea is partially reabsorbed 50%
- PCT
- loop of henle
- DCT
- collecting duct

contributing to osmotic gradient of the kidney

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6
Q

urea - secretion

A

remaining urea passes through DCT/ CD where its excreted into urine

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7
Q

water - reabsorption

A

water is reabsorbed
- PCT (70%)
- loop of henle -> descending limb NOT ascending limb
- DCT - regulated by ADH
- CD

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8
Q

water - secretion

A

dehydrated = water conserved = conc urine

overhydrated = water secreted out = diluted urine

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9
Q

sodium - reabsorption

A

sodium is actively reabsorbed

  • PCT
  • loop of henle - thick ascending
  • DCT
  • CD
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10
Q

sodium - secretion

A

some sodiums secreted in distal part of nephron
influenced by aldosterone

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11
Q

chloride - reabsorption

A
  • PCT passive
  • loop of henle - thick ascending - active
  • DCT/ CD - influenced by aldosterone
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12
Q

chloride - secretion

A

small amounts secreted in DCT/CD under certain conditions

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13
Q

potassium - reabsorption

A

PCT
loop of henle - thick of ascending limb

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14
Q

potassium - secretion

A

DCT
CD

  • influenced by aldosterone
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15
Q

phosphate - reabsorption

A

active reabsorption in PCT
- sodium-phosphate cotransporters

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16
Q

phosphate - secretion

A

minimal in kidneys

17
Q

calcium - reabsorption

A

active reabsorption

  • PCT - 70%
  • loop of henle - thick ascending - 20%
  • DCT - 10%
18
Q

calcium - secretion

A

calcium secretion in urine is minimal
depending on diet intake

19
Q

magnesium - reabsorption

A

PCT - 70%
loop of henle - thick ascending limb 30%
DCT

20
Q

magnesium - secretion

A

minimal

21
Q

H+ reabsorption

A

NOT

22
Q

H+ secretion

A

PCT - in exchange for sodium
DCT
CD

  • H+/ATPase
  • H+/L+-ATPase
23
Q

HCO3- reabsorption

A

PCT
loop of henle
DCT

24
Q

HCO3- secretion

A

NONE