Tuberculosis Flashcards
pathognomonic of miliary TB
choroidal tubercles
most common site of GI TB
ileum and terminal cecum
gold std of TB meningitis
CSF culture (Positive in 80%)
CNS TB contrast enhanced ring lesions
tuberculoma
induced by ESAT-6
MMP9 (recruits naive macromphages)
most potent risk factor for TB among affected individuals
HIV co infection
host responses that develop 2-4 weeks after MTB infection
1) macrophage-activating response
2) tissue damaging response
antigens of MTB that play a protective role
20kDa or 85B
ESAT-6
size of MTB
0.5 x 3 um
exacerbation in s and s in lab and xray manifestations of TB in adminisration of ART
Immune reconstitution inflammatory syndrome (IRIS)
when does IRIS occur
1-3 mos after administration of ART
patho IRIS
immune response elicited by antigens as bacilli are killed (in an improving immune function)
First priority in face of IRIS
ensure that this is not a failure of TB treatment, or development of another infection
Recommended daily dose
Isoniazid
5 mg/kg
max 300 mg
Recommended daily dose
Rifampin
10 mg/kg
max 600 mg
Recommended daily dose
Pyrazinamide
25 mg/kg
max 2 g
Recommended daily dose
Ethambutol
15 mg/kg
Age: highest incidence of TB
late adolescence
early adulthood
Molecular mechanism by which M tuberculosis induces granuloma formation
Mycobacterial protein ESAT-6
Two types of cells essential in the CMI response to TB
1) macrophages
2) T cells
The Ghon focus
Lesion forming after initial TB infection which is peripheral and accompanied by transient hillier or paratracheal lymphadenopathy
Ghon complex
Ghon focus with or without overlying pleural reaction and thickening and regional lymphadenopathy
Location of Post primary (Adult type) Tb disease
Apical and posterior segments of the upper lobes
**Superior segments of the lower lobes
“consumption”/ “phthisis”
classic galloping consumption of the past in TB
Most common presentation of extra pulmonary TB in both HIV seronegative and HIV patients
Tuberculous lymphadenitis
Most common location of Lymph node TB
posterior cervical and supraclavicular sites
% of Lymph node TB with concomitant pulmonary TB
50%