Leprosy Flashcards

0
Q

pathognomonic leprosy

A

invasion and destruction of nerves in the dermis by T cells

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1
Q

positive lepromin

A

tuberculoid leprosy

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2
Q

CD4 > CD8

A

tuberculoid leprosy

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4
Q

symmetric peripheral neuropathy

A

lepromatous leprosy

nerve enlargement and damage are symmetric and result from actual bacillary invasion

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5
Q

have a predominant Th1 response

A

tuberculoid leprosy

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6
Q

In leprosy, measure of the number of acid fast bacilli scrapings that stain uniformlybright

A

Morphologic index

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7
Q

incubation period of M Leprae

A

2 to 40 years

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8
Q

Explain the spectrum of leprosy

A

TT BT LT LL

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9
Q

Skin lesions of tuberculoid leprosy

A

one or few hypo pigmented macules or plaques

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10
Q

Late manifestations of lepromatous leprosy

A

Loss of eyebrows and lashes
pendulous earlobes
dry scaling skin

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11
Q

Type 1 lepra reactions

A

Downgrading and reversal reactions

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12
Q

Nerve trunk most common affected in downgrading and reversal reactions

A

ulnar nerve at the elbow

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13
Q

The most dramatic manifestation of Type 1 lepra reactions

A

footdrop

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14
Q

When type 1 lepra reactions precede the initiation of appropriate antimicrobial therapy

A

downgrading reactions

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15
Q

The most characteristic microscopic feature of Type 1 lepra reactions

A

edema

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16
Q

Type 2 lepra reaction

A

Erythema nodosum leprosum (ENL)