Leprosy Flashcards
pathognomonic leprosy
invasion and destruction of nerves in the dermis by T cells
positive lepromin
tuberculoid leprosy
CD4 > CD8
tuberculoid leprosy
symmetric peripheral neuropathy
lepromatous leprosy
nerve enlargement and damage are symmetric and result from actual bacillary invasion
have a predominant Th1 response
tuberculoid leprosy
In leprosy, measure of the number of acid fast bacilli scrapings that stain uniformlybright
Morphologic index
incubation period of M Leprae
2 to 40 years
Explain the spectrum of leprosy
TT BT LT LL
Skin lesions of tuberculoid leprosy
one or few hypo pigmented macules or plaques
Late manifestations of lepromatous leprosy
Loss of eyebrows and lashes
pendulous earlobes
dry scaling skin
Type 1 lepra reactions
Downgrading and reversal reactions
Nerve trunk most common affected in downgrading and reversal reactions
ulnar nerve at the elbow
The most dramatic manifestation of Type 1 lepra reactions
footdrop
When type 1 lepra reactions precede the initiation of appropriate antimicrobial therapy
downgrading reactions
The most characteristic microscopic feature of Type 1 lepra reactions
edema