Tuberculosis Flashcards
1
Q
Number of new cases of TB and death in 2017
A
8 million for new cases
2 millions of deaths
2
Q
Number of people infected by TB and active TB percentage?
A
2 billion affected by TB and 10% active TB
3
Q
How is TB transmitted ?
A
Airborne transmission
4
Q
What are the 5 damages of TB on the immune system
A
- live M. tuberculosis blocks phagosome maturation
- innate immune signalling (TLRs etc) shapes adaptive response
- immune response contains infection but does not eliminate pathogen
- breakdown of containment results in reactivation disease
- immune-mediated tissue damage important for transmission
5
Q
The role of T cell in TB cycle
A
Counteracts phagosome arrest so we can control the infection BUT not eliminating it
6
Q
What does INH drug inhibit ?
A
Mycolic acid synthesis ( component of the cell envelope)
