Herpesviruses Flashcards
1
Q
what’s the effect of HSV on host cell?
A
- Changes in host chromatin
- Changes in cellular membranes : duplication and folding of intracellular membranes, insertion of virus proteins in cell membrane, polykaryocytosis( several nuclei)
2
Q
what’s HSV entry?
A
Conjunctiva, finger (herpetic whitlow), other skin sites
3
Q
Pathogenesis of HSV-1
A
- Transmission via saliva or cold sores of infected individual
- virus replication in oral mucosa
3, mild febrile illness - vesicle ulcerate
- destruction epithelial cells
- virus enter sensory nerve endings - transfer to dorsal root ganglia
4
Q
When and where the VZV vaccine was firstly used ?
A
USA 1995
5
Q
What does EBV target ?
A
B-lymphocytes
6
Q
What does CMV target ?
A
Salivary glands and kidneys
7
Q
Effect of CMV on host cell
A
a’well behaved’ parasite, causing little or no damage to the host unless it infects the fetus or placenta to cause congenital abnormalities or it reactivates following depressed cell-mediated immunity (post-transplant, AIDS) to cause viremia, fever, hepatitis or pneumonia.
8
Q
Which year was HHV-6 firstly isolated ?
A
1986
9
Q
Where does HHV-6 replicate?
A
T and B cells
10
Q
What percentage of HHV6&7 are in the saliva
A
HHV-6 –> 85%
HHV-7–> 75%
