Tt ostéoporose Flashcards

1
Q

Biphosphonates

A

Alendronate PO : 70mg/s
Risédronate PO : 35mg/s ou 75mg/mois
Zolédrondate IV : 4mg/20min par an

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2
Q

Biphosphonates - CI

A

Hypocalcémie
Cl < 30ml/min

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3
Q

Biphosphonates - EI

A

Syndrome pseudo-grippal (IV++)
Toxicité digestive
Ostéonécrose de la mâchoire
Fracture atypique fémorale

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4
Q

Biphosphonate - activité

A

Antiostéoclastique

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5
Q

Dénosumab

A

Anticorps anti-RANK-L

Injection SC de 60mg/6 mois pendant 3 ans

Relais biphosphonate ++

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6
Q

Dénosumab - CI

A

Hypocalcémie

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7
Q

Dénosumab - EI

A

Ostéonécrose de la mâchoire
Fracture atypique de la hanche

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8
Q

Tériparatide

A

Analogue de la PTH
Ostéoblastique ++

20microg/j en SC pdt max 18 mois

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9
Q

Tériparatide - CI

A

Maladie de Paget
Ostéomalacie
HyperPTH sévère
Hypercalcémie
Atcd RX thérapie ou tumeur osseuse
IR sévère

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10
Q

Tériparatide - EI

A

Nausées
Céphalées
HypoTA

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