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Lundbeck > Trinellix Module 5 > Flashcards

Trinellix Module 5 Flashcards

1
Q

What is the MOA of Vilazodone?

A

Blocks SERT on the presynaptic nerve and binds to 5HT1a receptors on the pre and post synaptic neurons.

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2
Q

What is the Brand name for Zilazodone?

A

Viibryd

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3
Q

What is the mode of action for Vilazodone?

A

reuptake inhibition and receptor activity.

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4
Q

What are the key clinical trial outcomes for Vilazodone?

A

superior to placebo in improvment of depressive symptoms as measured by the mean change from baseline ti week 8 or 10 in the MADRS total score.

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5
Q

What are the common side effects of Vilazodone?

A

Diarrhea nausea insomnia vomiting

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6
Q

What is the MOA of Levomilnacopran?

A

Blocks reuptake of serotonin and Norepinephrine by blocking both the SERT and NET.

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7
Q

What is the Mode of action of levomilnacipran?

A

reuptake inhibition

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8
Q

What is the brand name for levomilnacipran?

A

Fetzima

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9
Q

What are the key clinical outcomes for levomilnacipran?

A

superior to placebo on improving depressive symptoms as measured by the MADRS
superior to placebo in improvements in the SDS functional impairment total score.

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10
Q

What are the common side effects of levomilnacipran?

A

nausea constipation, hyperhydrosis, tachycardia heart rate increase, erectile dysfunction vomiting palpitations and ejaculation disorder.

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11
Q

What is the brand name for duloxetine

A

Cymbalta

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12
Q

What is the MOA of duloxetine?

A

Blocks reuptake of serotonin and norepinephrine by blocking both the SERT and NET

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13
Q

What is the mode of action for duloxetine?

A

reuptake inhibition

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14
Q

What are the key clinical trial outcomes for duloxetine?

A

superior to placebo for improvement in the HAM-D

significantly longer time to relapse of Depression.

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15
Q

What are the common side effects of Duloxetine>

A

nausea, dry mouth, somnolence, constipation, decreases appetite, hyperhidrosis.

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16
Q

What is the brand name for desvenlafaxine?

A

Pristiq

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17
Q

What is the MOA of desvenlafaxine?

A

Blocks reuptake of serotonin and norepinephrine by blocking both the SERT and NET.

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18
Q

What is the mode of action of desvenlafaxine?

A

reuptake inhibition.

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19
Q

What are the key clinical trial outcomes for desvenlafaxine.

A

superior to placebo as assessed by the HAM-D and CGI-1

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20
Q

What are the common side effects of desceblafaxine?

A

nausea, dizziness insomnia hyperhydrosis, constipation, decreased appetite.

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21
Q

What is the brand name for venlafaxine?

A

Effexor

22
Q

What is the MOA for venlafaxine?

A

Blocks reuptake of serotonin and norepinephrine by blocking both the SERT and NET.

23
Q

What is the mode of action for venlafaxine?

A

reuptake inhibition

24
Q

What are the key clinical trial outcomes for venlafaxine?

A

signifigant improvment compared with placebo in numerous measures including the HAM-D total score, HAM-D depressed mood item and MADRS score, GCI-I and CGI-S.

25
Q

What are the common side effects for Venlafaxine?

A

nausea, somnolence, dry mouth, dizziness, constipation, nervousness, asthenia, sweating, anorexia.

26
Q

What is the brand name for bupropion?

A

Wellbutrin

27
Q

What is the MOA of bupropion?

A

Blocks the reuptake of NE and DA by blocking the NET and DAT

28
Q

What is the mode of action for bupropion?

A

reuptake inhibition

29
Q

What are the key clinical trial outcomes for bupropion?

A

greater efficacy on one or more measures including the HAM-D, MADRS, and CGI at days 21,28,35,42

30
Q

What are the common side effects of bupropion?

A

agitation, dry mouth, contipation, headache/migraine, weightloss, nasuea, excessive sweating, dizziness, tremor, sedation, insomnia, anorexia, blurred vision, weight gain, tachycardia.

31
Q

What is the brand name for sertraline?

A

Zoloft.

32
Q

What is the MOA of sertraline?

A

Bocks SERT, preventing reuptake and degradation of serotonin.

33
Q

What is the mode of action of sertraline?

A

reuptake inhibition

34
Q

What are the key clinical trial outcomes for sertraline?

A

superior to placebo on the HAM-D and CGI-S scales.

35
Q

What are the common side effects of sertraline?

A

Nausea, diarrhea, dry mouth, insomnia, somnolence, tremor, dizziness, fatigue.

36
Q

What is the brand name for citalopram?

A

Celexa

37
Q

What is the MOA of citalopram?

A

Blocks SERT, preventing reuptake and degradation of serotonin.

38
Q

What is the mode of action of citalopram?

A

reuptake inhibition

39
Q

What are the key clinical trial outcomes for citalopram?

A

Effective as measured by the HAM-D total score, HAM-D depressed mood item 1, MADRS, and CGI-S

40
Q

What are the common side effects of citalopram?

A

drymouth, increased sweating, nausea, somnolence, insomnia.

41
Q

What is the mechanism of action for escitalopram?

A

Blocks SERT, preventing reuptake and degradation of serotonin.

42
Q

What are the key clinical trial outcomes for escitalopram>

A

statistically significantly greater mean improvement compared to placebo on the MADRS.
Statistically significantly longer time to relapse compared with placebo.

43
Q

What are the common side effects for escitalopram?

A

insomnia, ejaculation disorder, nausea, somnolence, fatigue, increased sweating.

44
Q

What is the brand name for fluoxetine?

A

Prozac

45
Q

What id the MOA for fluoxetine?

A

Blocks SERT, preventing reuptake and degradation of serotonin.

46
Q

What is the mode of action for fluoxetin?

A

reuptake inhibition

47
Q

What are the key clinical trial outcomes for fluoxetin?

A

Adults: signifiganly more effective than placebo in HAM-D and subscores of HAM-D for the depressed mood, sleep disturbance, and the anxiety subfactor.
Elderly: Signifiganlty higher rate of response and remission compared to placebo as defined, respectively, by 50% decrease in the HAM-D score and total endpoint HAM-D score of <8

48
Q

What are the common side effects of Fluoxetin?

A

Nausea, insomnia, nervousness, somnolence, diarrhea, anxiety, anorexia, dry mouth, tremor.

49
Q

According to STAR*D study what should a physician do when a patient fails first line therapy.

A

They should switch treatment or augment treatment. although there is no proven benefit to choosing one over the other.

50
Q

Based on the finding of the STAR*D what percentage of patients with MDD achieved remission after the initial treatment?

A

33%

51
Q

According to the STAR*D findings what is the preferred goal of treatment for MDD and Why?

A

The preferred goal is remission, because it is associated with a better prognosis.

Lundbeck (9 decks)

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