Trinellix Module 5

Question 1

What is the MOA of Vilazodone?

Answer 1

Blocks SERT on the presynaptic nerve and binds to 5HT1a receptors on the pre and post synaptic neurons.

Question 2

What is the Brand name for Zilazodone?

Answer 2

Viibryd

Question 3

What is the mode of action for Vilazodone?

Answer 3

reuptake inhibition and receptor activity.

Question 4

What are the key clinical trial outcomes for Vilazodone?

Answer 4

superior to placebo in improvment of depressive symptoms as measured by the mean change from baseline ti week 8 or 10 in the MADRS total score.

Question 5

What are the common side effects of Vilazodone?

Answer 5

Diarrhea nausea insomnia vomiting

Question 6

What is the MOA of Levomilnacopran?

Answer 6

Blocks reuptake of serotonin and Norepinephrine by blocking both the SERT and NET.

Question 7

What is the Mode of action of levomilnacipran?

Answer 7

reuptake inhibition

Question 8

What is the brand name for levomilnacipran?

Answer 8

Fetzima

Question 9

What are the key clinical outcomes for levomilnacipran?

Answer 9

superior to placebo on improving depressive symptoms as measured by the MADRS
superior to placebo in improvements in the SDS functional impairment total score.

Question 10

What are the common side effects of levomilnacipran?

Answer 10

nausea constipation, hyperhydrosis, tachycardia heart rate increase, erectile dysfunction vomiting palpitations and ejaculation disorder.

Question 11

What is the brand name for duloxetine

Answer 11

Cymbalta

Question 12

What is the MOA of duloxetine?

Answer 12

Blocks reuptake of serotonin and norepinephrine by blocking both the SERT and NET

Question 13

What is the mode of action for duloxetine?

Answer 13

reuptake inhibition

Question 14

What are the key clinical trial outcomes for duloxetine?

Answer 14

superior to placebo for improvement in the HAM-D

significantly longer time to relapse of Depression.

Question 15

What are the common side effects of Duloxetine>

Answer 15

nausea, dry mouth, somnolence, constipation, decreases appetite, hyperhidrosis.

Question 16

What is the brand name for desvenlafaxine?

Answer 16

Pristiq

Question 17

What is the MOA of desvenlafaxine?

Answer 17

Blocks reuptake of serotonin and norepinephrine by blocking both the SERT and NET.

Question 18

What is the mode of action of desvenlafaxine?

Answer 18

reuptake inhibition.

Question 19

What are the key clinical trial outcomes for desvenlafaxine.

Answer 19

superior to placebo as assessed by the HAM-D and CGI-1

Question 20

What are the common side effects of desceblafaxine?

Answer 20

nausea, dizziness insomnia hyperhydrosis, constipation, decreased appetite.

Question 21

What is the brand name for venlafaxine?

Answer 21

Effexor

Question 22

What is the MOA for venlafaxine?

Answer 22

Blocks reuptake of serotonin and norepinephrine by blocking both the SERT and NET.

Question 23

What is the mode of action for venlafaxine?

Answer 23

reuptake inhibition

Question 24

What are the key clinical trial outcomes for venlafaxine?

Answer 24

signifigant improvment compared with placebo in numerous measures including the HAM-D total score, HAM-D depressed mood item and MADRS score, GCI-I and CGI-S.

Question 25

What are the common side effects for Venlafaxine?

Answer 25

nausea, somnolence, dry mouth, dizziness, constipation, nervousness, asthenia, sweating, anorexia.

Question 26

What is the brand name for bupropion?

Answer 26

Wellbutrin

Question 27

What is the MOA of bupropion?

Answer 27

Blocks the reuptake of NE and DA by blocking the NET and DAT

Question 28

What is the mode of action for bupropion?

Answer 28

reuptake inhibition

Question 29

What are the key clinical trial outcomes for bupropion?

Answer 29

greater efficacy on one or more measures including the HAM-D, MADRS, and CGI at days 21,28,35,42

Question 30

What are the common side effects of bupropion?

Answer 30

agitation, dry mouth, contipation, headache/migraine, weightloss, nasuea, excessive sweating, dizziness, tremor, sedation, insomnia, anorexia, blurred vision, weight gain, tachycardia.

Question 31

What is the brand name for sertraline?

Answer 31

Zoloft.

Question 32

What is the MOA of sertraline?

Answer 32

Bocks SERT, preventing reuptake and degradation of serotonin.

Question 33

What is the mode of action of sertraline?

Answer 33

reuptake inhibition

Question 34

What are the key clinical trial outcomes for sertraline?

Answer 34

superior to placebo on the HAM-D and CGI-S scales.

Question 35

What are the common side effects of sertraline?

Answer 35

Nausea, diarrhea, dry mouth, insomnia, somnolence, tremor, dizziness, fatigue.

Question 36

What is the brand name for citalopram?

Answer 36

Celexa

Question 37

What is the MOA of citalopram?

Answer 37

Blocks SERT, preventing reuptake and degradation of serotonin.

Question 38

What is the mode of action of citalopram?

Answer 38

reuptake inhibition

Question 39

What are the key clinical trial outcomes for citalopram?

Answer 39

Effective as measured by the HAM-D total score, HAM-D depressed mood item 1, MADRS, and CGI-S

Question 40

What are the common side effects of citalopram?

Answer 40

drymouth, increased sweating, nausea, somnolence, insomnia.

Question 41

What is the mechanism of action for escitalopram?

Answer 41

Blocks SERT, preventing reuptake and degradation of serotonin.

Question 42

What are the key clinical trial outcomes for escitalopram>

Answer 42

statistically significantly greater mean improvement compared to placebo on the MADRS. Statistically significantly longer time to relapse compared with placebo.

Question 43

What are the common side effects for escitalopram?

Answer 43

insomnia, ejaculation disorder, nausea, somnolence, fatigue, increased sweating.

Question 44

What is the brand name for fluoxetine?

Answer 44

Prozac

Question 45

What id the MOA for fluoxetine?

Answer 45

Blocks SERT, preventing reuptake and degradation of serotonin.

Question 46

What is the mode of action for fluoxetin?

Answer 46

reuptake inhibition

Question 47

What are the key clinical trial outcomes for fluoxetin?

Answer 47

Adults: signifiganly more effective than placebo in HAM-D and subscores of HAM-D for the depressed mood, sleep disturbance, and the anxiety subfactor. Elderly: Signifiganlty higher rate of response and remission compared to placebo as defined, respectively, by 50% decrease in the HAM-D score and total endpoint HAM-D score of <8

Question 48

What are the common side effects of Fluoxetin?

Answer 48

Nausea, insomnia, nervousness, somnolence, diarrhea, anxiety, anorexia, dry mouth, tremor.

Question 49

According to STAR*D study what should a physician do when a patient fails first line therapy.

Answer 49

They should switch treatment or augment treatment. although there is no proven benefit to choosing one over the other.

Question 50

Based on the finding of the STAR*D what percentage of patients with MDD achieved remission after the initial treatment?

Answer 50

33%

Question 51

According to the STAR*D findings what is the preferred goal of treatment for MDD and Why?

Answer 51

The preferred goal is remission, because it is associated with a better prognosis.