Trinellix Module 5 Flashcards
What is the MOA of Vilazodone?
Blocks SERT on the presynaptic nerve and binds to 5HT1a receptors on the pre and post synaptic neurons.
What is the Brand name for Zilazodone?
Viibryd
What is the mode of action for Vilazodone?
reuptake inhibition and receptor activity.
What are the key clinical trial outcomes for Vilazodone?
superior to placebo in improvment of depressive symptoms as measured by the mean change from baseline ti week 8 or 10 in the MADRS total score.
What are the common side effects of Vilazodone?
Diarrhea nausea insomnia vomiting
What is the MOA of Levomilnacopran?
Blocks reuptake of serotonin and Norepinephrine by blocking both the SERT and NET.
What is the Mode of action of levomilnacipran?
reuptake inhibition
What is the brand name for levomilnacipran?
Fetzima
What are the key clinical outcomes for levomilnacipran?
superior to placebo on improving depressive symptoms as measured by the MADRS
superior to placebo in improvements in the SDS functional impairment total score.
What are the common side effects of levomilnacipran?
nausea constipation, hyperhydrosis, tachycardia heart rate increase, erectile dysfunction vomiting palpitations and ejaculation disorder.
What is the brand name for duloxetine
Cymbalta
What is the MOA of duloxetine?
Blocks reuptake of serotonin and norepinephrine by blocking both the SERT and NET
What is the mode of action for duloxetine?
reuptake inhibition
What are the key clinical trial outcomes for duloxetine?
superior to placebo for improvement in the HAM-D
significantly longer time to relapse of Depression.
What are the common side effects of Duloxetine>
nausea, dry mouth, somnolence, constipation, decreases appetite, hyperhidrosis.
What is the brand name for desvenlafaxine?
Pristiq
What is the MOA of desvenlafaxine?
Blocks reuptake of serotonin and norepinephrine by blocking both the SERT and NET.
What is the mode of action of desvenlafaxine?
reuptake inhibition.
What are the key clinical trial outcomes for desvenlafaxine.
superior to placebo as assessed by the HAM-D and CGI-1
What are the common side effects of desceblafaxine?
nausea, dizziness insomnia hyperhydrosis, constipation, decreased appetite.
What is the brand name for venlafaxine?
Effexor
What is the MOA for venlafaxine?
Blocks reuptake of serotonin and norepinephrine by blocking both the SERT and NET.
What is the mode of action for venlafaxine?
reuptake inhibition
What are the key clinical trial outcomes for venlafaxine?
signifigant improvment compared with placebo in numerous measures including the HAM-D total score, HAM-D depressed mood item and MADRS score, GCI-I and CGI-S.
What are the common side effects for Venlafaxine?
nausea, somnolence, dry mouth, dizziness, constipation, nervousness, asthenia, sweating, anorexia.
What is the brand name for bupropion?
Wellbutrin
What is the MOA of bupropion?
Blocks the reuptake of NE and DA by blocking the NET and DAT
What is the mode of action for bupropion?
reuptake inhibition
What are the key clinical trial outcomes for bupropion?
greater efficacy on one or more measures including the HAM-D, MADRS, and CGI at days 21,28,35,42
What are the common side effects of bupropion?
agitation, dry mouth, contipation, headache/migraine, weightloss, nasuea, excessive sweating, dizziness, tremor, sedation, insomnia, anorexia, blurred vision, weight gain, tachycardia.
What is the brand name for sertraline?
Zoloft.
What is the MOA of sertraline?
Bocks SERT, preventing reuptake and degradation of serotonin.
What is the mode of action of sertraline?
reuptake inhibition
What are the key clinical trial outcomes for sertraline?
superior to placebo on the HAM-D and CGI-S scales.
What are the common side effects of sertraline?
Nausea, diarrhea, dry mouth, insomnia, somnolence, tremor, dizziness, fatigue.
What is the brand name for citalopram?
Celexa
What is the MOA of citalopram?
Blocks SERT, preventing reuptake and degradation of serotonin.
What is the mode of action of citalopram?
reuptake inhibition
What are the key clinical trial outcomes for citalopram?
Effective as measured by the HAM-D total score, HAM-D depressed mood item 1, MADRS, and CGI-S
What are the common side effects of citalopram?
drymouth, increased sweating, nausea, somnolence, insomnia.
What is the mechanism of action for escitalopram?
Blocks SERT, preventing reuptake and degradation of serotonin.
What are the key clinical trial outcomes for escitalopram>
statistically significantly greater mean improvement compared to placebo on the MADRS.
Statistically significantly longer time to relapse compared with placebo.
What are the common side effects for escitalopram?
insomnia, ejaculation disorder, nausea, somnolence, fatigue, increased sweating.
What is the brand name for fluoxetine?
Prozac
What id the MOA for fluoxetine?
Blocks SERT, preventing reuptake and degradation of serotonin.
What is the mode of action for fluoxetin?
reuptake inhibition
What are the key clinical trial outcomes for fluoxetin?
Adults: signifiganly more effective than placebo in HAM-D and subscores of HAM-D for the depressed mood, sleep disturbance, and the anxiety subfactor.
Elderly: Signifiganlty higher rate of response and remission compared to placebo as defined, respectively, by 50% decrease in the HAM-D score and total endpoint HAM-D score of <8
What are the common side effects of Fluoxetin?
Nausea, insomnia, nervousness, somnolence, diarrhea, anxiety, anorexia, dry mouth, tremor.
According to STAR*D study what should a physician do when a patient fails first line therapy.
They should switch treatment or augment treatment. although there is no proven benefit to choosing one over the other.
Based on the finding of the STAR*D what percentage of patients with MDD achieved remission after the initial treatment?
33%
According to the STAR*D findings what is the preferred goal of treatment for MDD and Why?
The preferred goal is remission, because it is associated with a better prognosis.
