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Antibiotics > Trimethoprim/sulfamethoxazole > Flashcards

Trimethoprim/sulfamethoxazole Flashcards

1
Q

Trimethoprim/sulfamethoxazole’s (TMP/SMX) action is to inhibit what cellular mechanism?

A

Inhibit DNA synthesis

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2
Q

TMP/SMX is an important antibiotic against pneumocystis jirovecii in what type of patients?

A

Immunocompromised, especially HIV

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3
Q

When looking up the dose of TMP/SMX, what component is listed as the dose?

A

Trimethoprim (TMP)

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4
Q

What is the Trimethoprim:Sulfamethoxazole ratio?

A

1:5

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5
Q

What is the threshold for decreasing the dose of TMP/SMX by 50%?

A

Crcl < 30 cc/hr

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6
Q

Trimethoprim can increase Cr both by inducing renal insufficiency and _____.

A

Blocking active secretion of creatinine

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7
Q

Folic acid may mitigate side effects in patients on TMP/SMX. Which patients should not get supplementation?

A

HIV patients

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Antibiotics (11 decks)

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