Aminoglycosides Flashcards
Aminoglycosides target what part of the bacterial system?
The 30s subunit of the ribosome
Aminoglycosides typically cover what?
Aerobes, some gram (+) and (-)
What is one typical indication of monotherapy with aminoglycosides?
Tularemia, plague, UTI with many gram (-), neisseria gonorrhoeae
Aminoglycosides exhibit what three effects?
Post-antibiotic effect
Concentration Dependant Killing effect
Synergistic effect
The post-antibiotic effect is seen in what type of infections?
Staph and gram (-)
Synergy typically occurs with aminoglycosides and what type of antibiotics?
Beta-lactams
Aminoglycosides are associated with the side effect of potential damage to the tissues of what two areas?
The kidney and the inner ear
When used in combination with neuromuscular blockade, side effects of aminoglycosides include
Paralysis
Which aminoglycoside can be inhaled to treat cystic fibrosis?
Tobramycin
