Tricyclics

Question 1

How do tricyclics work?

Answer 1

Work by blocking the serotonin transporter and the norepinephrine transporter.

Results in increased concentration of serotonin and
norepinephrine at the synapse

Leads to increased neurotransmission

Question 2

Do tricyclics affect dopamine?

Answer 2

Mostly no

Question 3

Tricyclics also have antagonistic effects on ______ and ________ receptors which lead to many of its side effects

Answer 3

Tricyclics also have antagonistic effects on HISTAMINE and muscarinic acetylcholine receptors which lead to many of its side effects

Question 4

Which 2 channels do tricyclics also affect, leading to cardio toxic effects?

Answer 4

Sodium and Calcium

Question 5

What are the tricyclics? (6)

Answer 5

Clomipramine 
Amitriptyline
Despipramine
Doxepine
Imipramine
Nortriptyline

CADDIN.
Tri-CAD
Cam always dance dances in Tricycles.. Tricyclics

Question 6

Brand name for Amitriptyline

Answer 6

Elavil

AmiEla.. AmitriptylinE

Question 7

Brand name for Clomipramine

Answer 7

Anafranil

Clo(m) & Ana worked together.. Clomipramine

Question 8

Brand name for Despipramine

Answer 8

Norpramin

Desp-erate was Nor to be seen as non-Brown.. Despipramine

Question 9

Brand name for Doxepine

Answer 9

Silenor

With Dox-y, you can keep PHI Silen-t.. Doxepine

Question 10

Brand name for Imipramine

Answer 10

Tofranil

Im To-eing the nil mine.. Imipramine

Question 11

Brand name for Nortriptyline

Answer 11

Pamelor

Noor & Pam are Brown.. Nortriptyline

Question 12

Common side effects for Tricyclics? (4 main)

Answer 12

anticholinergic - dry mouth and skin, blurred vision, constipation, and difficulty urinating (retention);

confusion and delirium in elderly;

drowsiness and sedation in elderly;

weight gain

Question 13

Tricyclic precautions?

Answer 13

Orthostatic hypotension, can lead to fainting;
withdrawal sxs; 
sexual dysfunction; 
SI;
drowsiness & blurred vision; 
cardiac arrhythmia;
serotonin syndrome

Question 14

Tricyclics block the ________ transporter AND the ________ transporter

Answer 14

Tricyclics block the serotonin transporter AND the norepinephrine transporter

Question 15

As for mechanism, tricyclics results in increased/decreased concentration of serotonin and NE at the synapse?

Answer 15

Increased

tricyclics result in increased concentration of serotonin and norepinephrine at the synapse

Question 16

Do tricyclics mostly do or do not affect dopamine?

Answer 16

Do not

tricyclics mostly do NOT effect dopamine