Atypical Agents Flashcards
Brand name for Bupropion
Wellbutrin SR, Wellbutrin XL, Zyban, Aplenzin, Forfivo XL
“Bups” is all well w/ me… Wellbutrin
Common Bupropion side effects / precautions?
tremors, insomnia, seizures, SI in children
Babies with bupropion exposure during the ______ trimester found to be more likely to have some heart problems
1st!
Abrupt discontinuation of bupropion leads to ______
withdrawal
Brand name for Mirtazapine
Remeron
Mirta is old & will be REMembered … Mirtazapine
Commonalities of atypical agents? (precautions)
seizure, some SI
What are the 2 atypical agents?
- Bupropion - Wellbutrin SR, Wellbutrin XL, Zyban, Aplenzin, Forfivo XL
- Mirtazapine – Remeron
BM
Body Mass is sometimes Atypical
Does Bupropion act on serotonin?
No
Bupropion does not act on serotonin
Bupropion is a: _______ reuptake inhibitor AND ______ reuptake inhibitor
NE and DA
Bupropion is a norepinephrine reuptake inhibitor AND Dopamine reuptake inhibitor
Need a ____ day washout period between _____ and bupropion to avoid a hypertensive crisis
14 day; MAOI
Need a 14 day washout period between MAOI and bupropion to avoid a hypertensive crisis
True or False: Bupropion and Mirtazapine are safer than tricyclics
True
Bupropion and Mirtazapine are safer than tricyclics
Is Mirtazapine an agonist OR antagonist of serotonin receptors?
Antagonist
Mirtazapine is antagonist of certain serotonin receptors
DOES NOT work by blocking reuptake
Antagonist of Alpha 2 receptor
Leads to inhibition of the inhibitor –> increase norepinephrine
Mirtazapine is an antagonist of which receptor?
Alpha 2
Mirtazapine is an Antagonist of Alpha 2 receptor
Leads to inhibition of the inhibitor –> increase norepinephrine
Mirtazapine leads to inhibition/excitation of the inhibitor –> increase/decrease norepinephrine
inhibition/increase
Mirtazapine leads to inhibition of the inhibitor –> increase norepinephrine
Most serious rx of Bupropion and Mirtazapine?
Most serious reaction is seizure
Bupropion and Mirtazapine most serious rx
