SSRIs

Question 1

Brand name of Citalopram

Answer 1

Celexa

Celexa “cits” on the pram

Question 2

Brand name of Escitalopram

Answer 2

Lexapro

Lexa ES “cits” on the pram.. Escitalopram

Question 3

Brand name(s) of Fluoxetine

Answer 3

Prozac/Sarafem

Oh, who had the FLU, oh?
Poor Proz(ac) & stuffy Sara(fem) had the Flu.. Fluoxetine

Question 4

Brand name of Fluvoxemine

Answer 4

Luvox

Even Fluv needs some Luv! <3

Question 5

Brand name(s) of Paroxetine

Answer 5

Paxil, Brisdelle, Pexeva

Who is a paradox?
PaxBriPex is like a Paradox.. Paroxetine

Question 6

Brand name of Sertraline

Answer 6

Zoloft

Sert-ainly, there are many Zoloft ads everywhere

Question 7

Which are the more “activating” of SSRIs?

Answer 7

Fluoxetine, Paroxetine

Oh flu & the paradox are bad

Question 8

Which is associated w/ baby malformations in 1st trimester?

Answer 8

Paroxetine

Question 9

Adverse rxs of SSRIs? (3)

Answer 9

Adverse rxs of SSRIs? (3)

1) trigger mania in pts with BP
2) serotonin syndrome
3) syndrome of inappropriate antidiuretic hormone secretion (SIADH)

Question 10

What is syndrome of inappropriate antidiuretic hormone secretion (SIADH)?

Answer 10

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a condition in which the body makes too much antidiuretic hormone (ADH). This hormone helps the kidneys control the amount of water your body loses through the urine. SIADH causes the body to retain too much water

Question 11

What are the SSRIs? (6)

Answer 11

• Paroxetine – Paxil, Brisdelle, Pexeva
• Sertraline – Zoloft
• Citalopram – Celexa
• Escitalopram – Lexapro
• Fluoxetine – Prozac/Sarafem
• Fluvoxemine – Luvox

SSRIs = CEFFSPS

P.S. listen to myCEFF!

Question 12

___________ neurotransmission is the neural basis for mood, reward, pleasure, motivation, and related cognitive and executive functions

Answer 12

Monoaminergic

Monoaminergic neurotransmission is the neural basis for mood, reward, pleasure, motivation, and related cognitive and executive functions

Question 13

Aberrant DA and NE signaling –> adversely influence ______ and related ________

Answer 13

motivation and EF

Aberrant DA and NE signaling –> adversely influence motivation and related executive functions

Question 14

Impaired _______ neurotransmission –> anhedonia, guilt, and similar ‘negative affects’ of depression

Answer 14

Serotonin/5HT

Impaired serotonin/5HT neurotransmission –> anhedonia, guilt, and similar ‘negative affects’ of depression

Question 15

_______ and _______ have descending spinal pathways that mediate physical fatigue and related somatic symptoms

Answer 15

Serotonin/5HT and NE

Serotonin/5HT and NE have descending spinal pathways that mediate physical fatigue and related somatic symptoms

Question 16

Do SSRIs result in more or less serotonin being available in the synapse?

Answer 16

More!

It results in more serotonin being available in the synapse and thus an amplified transmission.

Question 17

What happens if serotonin syndrome goes untreated?

Answer 17

if serotonin syndrome goes untreated:

elevated temperature and blood pressure, excessive muscle tension, muscle breakdown (rhabdomyolysis), kidney failure, coma, and death

Question 18

Where is Antidiuretic Hormone (ADH) released and stored?

Answer 18

Antidiuretic Hormone (ADH) is released by hypothalamus and stored in the posterior pituitary

Question 19

Antidiuretic Hormone (ADH) acts on what organ and does what?

Answer 19

ADH acts on the kidneys to retain/reabsorb more water

Question 20

SIADH: syndrome of inappropriate antidiuretic hormone secretion can result in a higher blood volume, aka ________

Answer 20

hypervolemia

SIADH: syndrome of inappropriate antidiuretic hormone secretion can result in a higher blood volume hypervolemia

Question 21

SIADH: syndrome of inappropriate antidiuretic hormone secretion can lead to a dilutional lowering of the blood’s sodium concentration, aka _________

Answer 21

hyponatremia

SIADH: syndrome of inappropriate antidiuretic hormone secretion can lead to a dilutional lowering of the blood’s sodium concentration, aka hyponatremia

Question 22

True or False: SSRIs should not be stopped abruptly as this will result in discontinuation syndrome

Answer 22

True!

SSRIs should not be stopped abruptly as this will result in discontinuation syndrome

Question 23

True or False: SSRIs pass into breast milk, if patient can not stop the medication breast-feeding should not be started

Answer 23

True

SSRIs pass into breast milk, if patient can not stop the medication breast-feeding should not be started

Question 24

Babies exposed to SSRI antidepressants late in the _________ trimester of pregnancy may develop complications after birth:
respiratory distress, cyanosis (bluish skin tone from lack of oxygen), irritability, tremor, constant crying, feeding difficulty, and other symptoms.

Answer 24

Babies exposed to SSRI antidepressants late in the THIRD trimester of pregnancy may develop complications after birth:
respiratory distress, cyanosis (bluish skin tone from lack of oxygen), irritability, tremor, constant crying, feeding difficulty, and other symptoms.

Question 25

True or False: SSRIs are NOT safer than Tricyclic’s and MAOIs

Answer 25

False

SSRIs are Safer than Tricyclic’s and MAOIs.

Fatalities are rare with SSRIs, and most cases of fatalities result from combining other drugs.

Question 26

Regarding Citalopram/Escitalopram, which is the “purified” form?

Answer 26

Escitalopram

Escitalopram is the purified form of citalopram (Celexa).

Question 27

Regarding Citalopram/Escitalopram, is the S or the R form the primary source of antidepressant activity?

Answer 27

S

It is thought that the S form is the primary source of the antidepressant action and that the R form has little or no antidepressant activity but may interfere with the active molecule and contribute to side effects.

Question 28

Does fluoxetine has a LONG or SHORT half-life?

Answer 28

Long

Because fluoxetine has a long half-life, high levels may be prolonged