Trematodes Flashcards
aka FLUKES
TREMATODES
appearance of adult TREMATODES
Leaf-like
TREMATODES: monoecious or dioecious
Monoecious
Infective stage of trematodes
Metacercaria (last larval stage of trematodes)
Means of trematodes in attaching themselves to the host
2 suckers (oral and ventral/acetabulum)
2 suckers of trematodes
Oral sucker
Ventral sucker (acetabulum)
How many suckers does trematodes have? Is there an exception?
2 suckers (oral and ventral/acetabulum)
Exception: Heterophyes heterophyes = 3rd sucker: genital sucker/gonotyl
No. and type of host required by trematodes
2 INTERMEDIATE HOSTS
1st IH: Snail
2nd IH: Fish, crabs, vegetation, snail
General MOT of trematodes
Ingestion of the 2nd intermediate host infected with Metacercaria
Give some habitats of trematodes
Liver
Intestines
Pancreas
Lungs
describe the egg stage of trematodes
Eggs – has operculum (lid-like; allows exit of larva from the egg when they hatch)
lid-like structure that allows the exit of larva from the egg when they hatch
operculum
larval stage of trematodes
(5 sub-stages) – “My Sister Rent a Car for Me”
* Miracidium
* Sporocyst
* Redia
* Cercaria
* Metacercaria – infective stage
describe the adult stage of trematodes
Oviparous or Oviviparous
Enumerate FASCIOLIDS
- Fasciola hepatica – liver fluke
- Fasciola gigantica – liver fluke
- Fasciolopsis buski – intestinal fluke
Enumerate HETEROPHYIDS
- Clonorchis sinensis
- Opisthorchis felineus
- Heterophyes heterophyes
- Metagonimus yokogawai
Enumerate INTESTINAL FLUKES
Fasciolopsis buski
Echinostoma ilocanum
Heterophyes heterophyes
Metagonimus yokogawai
Enumerate LIVER FLUKES
Fasciola hepatica
Fasciola gigantica
Clonorchis sinensis
Opisthorchis felineus
Dicrocoelium dendriticum/ lanceolata
LUNG FLUKE
Paragonimus westermani
PANCREATIC FLUKE
Eurytrema pancreaticum
Enumerate SCHISTOSOMES / BLOOD FLUKES
Schistosoma japonicum
Schistosoma mansoni
Schistosoma haematobium
Schistosoma mekongi
Schistosoma intercalatum
aka Giant Intestinal Fluke
Fasciolopsis buski
Largest fluke parasitizing man
Fasciolopsis buski
larger than F. gigantica
Fasciolopsis buski
FINAL HOST of Fasciolopsis buski
Man
1ST IH of Fasciolopsis buski
Snails:
* Segmentina
* Hippeutis
2ND IH of Fasciolopsis buski
Vegetation:
* Water Caltrop (Trapa bicornis)
* Water Chestnut (Eliocharis tuberosa)
* Kangkong/Morning Glory (Ipomea obscura)
* Lotus (Nymphaea lotus)
* Bamboo shoots (Zizania latifolia)
Habitat of Fasciolopsis buski
Small intestine
Infective stage of Fasciolopsis buski
Metacercaria
PATHOLOGY: Fasciolopsis buski
Abdominal discomfort
Diarrhea
Edema
Lab dx of Fasciolopsis buski
Stool examination
Concentration techniques
Molecular techniques
Drug of choice for Fasciolopsis buski
Praziquantel
Adult form has:
- simple intestinal ceca
- 2 dendritic testes in tandem
- branched ovaries
Fasciolopsis buski
Egg of Fasciolopsis buski
Indistinguishable from other fasciolid ova
aka Garrison’s Fluke
Echinostoma ilocanum
Discovered by Philip Garrison among prisoners of Bilibid Prison in Manila, PH
Echinostoma ilocanum
FINAL HOST of Echinostoma ilocanum
Man
1ST IH of Echinostoma ilocanum
Snails:
* Gyraulus convexiusculus
* Hippeutis umbilicalis
2ND IH of Echinostoma ilocanum
Snails:
* Kuhol (Pila luzonica)
* Susong Pampang (Vivipara angularis)
Habitat of Echinostoma ilocanum
Small intestine
Infective stage of Echinostoma ilocanum
Metacercaria
PATHOLOGY: Echinostoma ilocanum
Abdominal discomfort
Chronic mucous diarrhea
Eosinophilia
Lab dx of Echinostoma ilocanum
Stool examination
Concentration techniques
Molecular techniques
Drug of choice for Echinostoma ilocanum
Praziquantel
Adult is described having Circumoral disk with crown of spines (49-51 spines) surrounding the oral sucker
Echinostoma ilocanum
Describe Echinostoma ilocanum egg
Germ ball egg with triangular operculum
Germ ball egg with triangular operculum
Echinostoma ilocanum egg
aka
Von Siebold’s Fluke
Heterophyid Fluke
Heterophyes heterophyes
Smallest trematode of man
Heterophyes heterophyes
Deadliest trematode (can migrate to brain, heart, spinal cord)
Heterophyes heterophyes
Heterophyes heterophyes migration to the heart (15% of the fetal heart disease)
Heterophyid myocarditis
FINAL HOST of Heterophyes heterophyes
Man
1ST IH of Heterophyes heterophyes
Snails:
* Cerithidea
* Pirenella
2ND IH of Heterophyes heterophyes
Fishes:
* Balanak (Mugil spp.)
* Tilapia (Tilapia spp.)
* Kanduli (Arius manilensis)
HABITAT of Heterophyes heterophyes
Small intestine
INFECTIVE STAGE of Heterophyes heterophyes
Metacercaria
PATHOLOGY: Heterophyes heterophyes
Abdominal pain
Mucous diarrhea
Ulceration of intestinal wall
Lab dx for Heterophyes heterophyes
Stool examination
Concentration techniques
Molecular techniques
Drug of choice for Heterophyes heterophyes
Praziquantel
Adult has:
- genital sucker surrounding genital pore
- 3rd sucker: genital sucker (gonocyte/gonotyl)
Heterophyes heterophyes
Old-fashioned light bulb egg
Heterophyes heterophyes
Metagonimus yokogawai
Different characteristic from other heterophyids: NO protuberance at the abopercular end
Old-fashioned light bulb egg of Heterophyes heterophyes and Metagonimus yokogawai
how do you differ M. yokogawai egg with H. heterophyes
M. yokogawai: thinner shell (still not a basis for differentiation)
aka Yokogawa’s Fluke
Metagonimus yokogawai
1ST IH of Metagonimus yokogawai
Snails:
* Semisulcospira
* Thiara
* Hua
2ND IH of Metagonimus yokogawai
Fishes:
* Salmonoid
* Cyprinoid
Habitat of Metagonimus yokogawai
Small intestine
Infective stage of Metagonimus yokogawai
Metacercaria
PATHOLOGY: Metagonimus yokogawai
Abdominal pain
Mucous diarrhea
Ulceration of intestinal wall
Lab dx for Metagonimus yokogawai
Stool examination
Concentration techniques
Molecular techniques
Drug of choice for Metagonimus yokogawai
Praziquantel
Adult is:
Pyriform-shaped
Scaly spines
NO gonotyl
Metagonimus yokogawai
Describe the egg of Metagonimus yokogawai
Old-fashioned light bulb
Describe the egg of Heterophyes heterophyes
Old-fashioned light bulb
Describe the adult form of Fasciolopsis buski
Has simple intestinal ceca
2 dendritic testes in tandem
Branched ovaries
Describe the adult form of Echinostoma ilocanum
Circumoral disk with crown of spines (49-51 spines) surrounding the oral sucker
No. of spines of Echinostoma ilocanum
49-51 spines
Describe the adult form of Heterophyes heterophyes
Has genital sucker surrounding genital pore
3rd sucker: genital sucker (gonocyte/gonotyl)
Describe the adult form of Metagonimus yokogawai
Pyriform-shaped
Scaly spines
NO gonotyl
Intestinal fluke with fishes as their 2nd IH
Heterophyes heterophyes
Metagonimus yokogawai
Intestinal fluke with snails as their both 1ST and 2ND IH
Echinostoma ilocanum
Intestinal fluke with vegetation as their 2ND IH
Fasciolopsis buski
aka
Sheep Liver Fluke
Temperate Liver Fluke
Fasciola hepatica
Natural/final host of Fasciola hepatica
Sheep
1st IH of Fasciola hepatica
Snails:
* Lymnea philippinensis
* Lymnea auricularia rubiginosa
Accidental host of Fasciola hepatica
Man
2nd IH of Fasciola hepatica
Vegetations:
* Kangkong (Ipomea obscura)
* Water cress (Nasturtium officinale)
Habitat of Fasciola hepatica
Liver parenchyma, gall bladder
Infective stage of F. hepatica
Metacercaria
Pathology of F. hepatica
Fascioliasis / sheep liver rot
Liver atrophy
Pharyngeal suffocation
result of the temporary lodgment of F. hepatica in pharynx
Pharyngeal suffocation
Pharyngeal suffocation term originated from Lebanon
Halzoun
Pharyngeal suffocation term originated from Sudan
Mararra
Lab dx for F. hepatica
Stool examination
Liver biopsy
PCR
Drug of choice for F. hepatica
Bithionol
Triclabendazole
Adult form:
- With cephalic cone
- Well-developed shoulder
Fasciola hepatica
Adult form:
- Larger than F. hepatica
- Shorter cephalic cone
- Less developed shoulder
Fasciola gigantica
describe larval stage of both F. hepatica and gigantica
ALL STAGES PRESENT
with Hen’s egg shape
ALL FASCIOLIDS EGG
Describe F. hepatica adult
With cephalic cone
Well-developed shoulder
Describe F. gigantica adult
Larger than F. hepatica
Shorter cephalic cone
Less developed shoulder
describe fasciolid eggs
- Large
- Operculated
- Unembryonated
- Yellowish-brown
aka
Giant Liver Fluke
Tropical Liver Fluke
Fasciola gigantica
Largest liver fluke
Fasciola gigantica