Tregs Flashcards
1
Q
Where is CD25 usually found?
A
on activated T cells
2
Q
What are Tregs normally called?
A
CD4+,
CD25+
T cells (Th3)
theses are the subset of tregs
3
Q
What is the function of Tregs?
A
found to suppress some self-reactive (e.g. autoimmune) cells
these cells have intermediate affinity for self-antigens (so they can become activated and suppress other immune cells-dont cause autoimmune disease
4
Q
What happens if a treg is shut off?
A
Autoimmune disease
5
Q
What is foxp3?
A
plays a functioning role in tregs
6
Q
What happens in a mutation in foxp3?
A
autoimmunity
