Central and peripheral tolerance Flashcards
1
Q
What in central tolerance?
A
Cells are recognized are screened as self and destroyed
2
Q
What happens to cells that are not destroyed by central tolerance?
A
maintained by tolerance (anergy)
3
Q
What is anergy?
A
tolerance-nonresponsiveness to an antigen
4
Q
How does some self reactive b cells become anergic?
A
become anergic if recognize antigen with no T cell help
if self-reactive T cell is deleted (central tolerance), then do not see T cell help for the B cell = anergy/apoptosis
5
Q
How does T cells need become anergic?
A
co-stimulation
6
Q
What does t cells need to be co stimulation in becoming anergic?
A
primarily CD28:B7
CTLA-4 sends inhibitory signal when bind to b7
7
Q
what is CTLA-4 responsible for?
A
control of an on-going immune response (“off” switch)
