Autoimmune diseases due to stimulating/blocking antibodies (SLE)

Question 1

What is Myasthenia gravis?

Answer 1

progressive skeletal muscle weakness

Question 2

What is the pathology for Myasthenia gravis?

Answer 2

blocking antibodies to acetylcholine receptors on muscles (C’ lysis of cells)

Question 3

What are therapies for Myashenia gravis?

Answer 3

-immunosuppression)if suppress too much could mess up immune system)

plasmapheresis-taking out blood and filtering out antibody and putting it back in patient and

(very common) IVIG-collecting polyclonal antibodies, putting them into patient. ti many Antibodies b cells shut down. antibodies also bind to Fc

Question 4

what is Systemic lupus erythematosus?

Answer 4

production of autoantibodies to:
DNA, histones, RBCs, platelets, clotting factors, etc.
they are called anti-nuclear antibodies (ANA)

Question 5

What is the symptoms of SLE?

Answer 5

systemic – fever, weakness, arthritis, skin rashes (butterfly rash over cheeks), kidney dysfunction, etc.

Question 6

What forms with SLE?

Answer 6

immune complexes form = C’ lysis of cells, inflammation

damage to blood vessels (kidney) – organ damage