Autoimmune diseases with direct cellular damage (thyroiditis, IDDM) Flashcards
1
Q
What is Hashimoto’s thyroiditis?
A
hypothyroidism- lack of iodine uptake destroys cells of the thyroid gland
autoantibodies AND Th1 cells (see DTH; ADCC)
2
Q
Who primiraly gets hashimotos thyroiditis?
A
primarily in middle-aged women
especially those of Japanese descent (genetics and environmental)
3
Q
What is autoimmune anemia?
A
autoantibodies to intrinsic factor (needed for uptake of Vit. B12)
4
Q
What is the cause of insulin dependent diabetes mellitus?
A
CTL attack of pancreatic islet beta-cells
Abs can play a role (C’ lysis and/or ADCC)
