Treatments 3 Flashcards
Trauma assessment, primary
ABCDE
Airway (ET/cricothyroid)
Breathing (O2, pulse ox, ventilation, pneumothorax)
Circulation (pulse, vitals, IVF x2 PIVs or central line, bleeding)
Disability (GCS, glucose)
Exposure (remove clothes, DRE/Foley, blanket)
Trauma assessment, secondary
Reassess ABCs DRE/Foley (not if high riding prostate/blood at urethral meatus) NGT placement Hx Head-to-toe exam Examine back, remove backboard X-rays, FAST, CT, labs, fx management
Lower ICP
Head of bed at 30 degrees
Mannitol IV (q6 hrs Na and osmolarity)
Intubate and hyperventilate (temp relief)
Decompressive craniectomy
Ventriculostomy, barbiturate coma, paralysis
Neck trauma, zone I
Clavicles to cricoid
CT angiogram, EGD, bronchoscopy, laryngoscopy
Neck trauma, zone II
Cricoid to angle of mandible
Surgical exploration
Neck trauma, zone III
Angle of mandible to base of skull
CT angiogram, EGD, bronchoscopy, laryngoscopy
Abdominal trauma, penetrating injury
(Emergent) exploratory laparotomy
Pelvic fx + DPL shows blood in pelvis
Emergent laparotomy
Pelvix fx + DPL shows urine in pelvis
Urgent laparotomy (bladder repair)
Pelvic fx + DPL shows nothing + hemodynamically unstable
Angiography + possible embolization
BAT + unstable vital signs + FAST shows fluid in pelvis
Emergent laparotomy
BAT + unstable vital signs + FAST shows no fluid in pelvis
Angiography + possible embolization
BAT + unstable vital signs + FAST inconclusive
DPL
BAT + stable vital signs
CT abdomen/pelvis, observation
Tension pneumothorax
Immediate chest tube placement
Needle decompression if CT delayed (2/3rd IC space mid-clavicular or 5th IC midaxillary)
Flail chest
O2
BiPAP or ET
Analgesia
Gonorrhea prophylaxis
Ceftriaxone 125 mg IM
Chlamydia prophylaxis
Azithromycin 1 g PO or
Doxycycline 100 mg PO bid x7 days
Trichomonas prophylaxis
Metronidazole 2 mg PO
Post-op to improve pulmonary fxn
Incentive spirometry
Deep breathing exercises
PT
Analgesia
Pre-op labs concerning for liver disease
Increased PT/PTT
Decreased platelets
Decreased albumin
Increased bilirubin
Obstruction (abdominal)
Surgical lysis of adhesions
Diverticulitis
Metronidazole and fluoroquinolone (PO outpatient or IV inpatient)
Massive GI hemorrhage (perforation)
Angiography w/ embolization, surgical repair of detectable site of bleeding
Appendicitis
Appendectomy
Acute mesenteric ischemia
NPO
NG tube
Antibiotics
Resection of necrotic bowel
Malignant hyperthermia
Evaporative cooling
Dantrolene
Cold inhaled O2, GI lavage, IV fluids
Chronic mesenteric ischemia
Bypass, endarectomy, or angioplasty and stenting
Graft vs. host disease
Corticosteroids
Tacrolimus, mycophenolate
Hyperacute transplant rejection
(First 24 hrs)
Untreatable
Acute transplant rejection
(6 days - 1 year)
Immunosuppressive agents
Chronic transplant rejection
(>1 year)
Usu untreatable
Immunosuppressive agents may help a bit
Common cold
Rest, analgesia, symptomatic treatment
NO Abx
Pharyngitis
Self-limited
Abx reduce infection time, reduce acute rheumatic fever (B-lactams)
Peritonsillar abscess
Needle aspiration or I&D
Pain meds + abx (amoxicillin/clavulanate or clindamycin)
Sinusitis
Symptomatic (nasal irrigation, analgesics, oral decongestants, intranasal steroids)
Amoxicillin-clavulanata, doxycycline or levofloxacin
PNA in neonates
Amp + gent +/- vancomycin
PNA in 1-4 months
Macrolides (-mycin) +/- cefotaxime
PNA in 4 months - 4 years
Amoxicillin, Ampicillin
PNA in 5-15 years
Amoxicillin + clarithromycin
Azithromycin
Amoxicillin + doxycycline
Acute bronchitis
Azithromycin, erythromycin, tetracycline, fluoroquinolone
Viral PNA
Self-limited
Strep pneumo PNA
B-lactam, macrolide (-mycin)
H. influenzae PNA
B-lactam, TMP-SMX
S. aureus PNA
B-lactam, MRSA coverage (vancomycin, etc)
Klebsiella PNA
Cephalosporin + aminoglycoside (gentamicin, tobramycin)
Pseudomonas PNA
Antipseudomonal B-lactam (piperacillin-tazobactam, cefepime, imipenem, meropenem, aztreonam) + one or two of following:
Antipseudomonal quinolone (cipro or levofloxacin)
Aminoglycoside (tobramycin, gentamicin or amikacin)
Azithromycin
GBS PNA
B-lactam (+ gentamicin in neonates)
Enterobacter PNA
TMP-SMX
Mycoplasma PNA
Macrolides (-mycin)
Legionella PNA
Macrolides (-mycin), fluoroquinolones (-floxacin)
Chlamydophila PNA
Doxycycline, macrolides (-mycin)
Coccidiomycosis PNA
Amphotericin B or Ketoconazole (systemic)
Fluconazole
Histoplasmosis PNA
Amphotericin B or Ketoconazole (systemic)
Itraconazole
Blastomycosis PNA
Amphotericin B or Ketoconazole (systemic)
Itraconazole
Latent TB (asymptomatic +PPD)
INH x 9 months
Primary or secondary active TB
Rifampin, Isoniazid Pyrazinamide, Ethambutol x 4 months
THEN Rifampin and Isoniazid x 2 months
Vitamin B6 w/ INH to prevent peripheral neuritis
ARDS
ICU, treat underlying cause
Mechanical ventilation w/ low tidal volume, adequate PEEP
Conservative fluid management
Mild intermittent asthma
Inhaled short acting B2 agonist
Mild persistent asthma
Inhaled short acting B2 agonist +
Low dose inhaled corticosteroid
Moderate persistent asthma
Inhaled short acting B2 agonist +
Low-medium dose inhaled corticosteroid +
Long acting B2 agonist
Consider LT inhibitor, ipratropium
Severe asthma
Inhaled short acting B2 agonist + High dose inhaled corticosteroid + Long acting B2 agonist Consider LT inhibitor, ipratropium Consider systemic steroids, theophylline
Asthma + persistent allergic rhinitis
LT inhibitor (montelukast, zafirlukast, zileuton)
COPD A (Gold 1-2, mild sx)
Short acting bronchodilator (albuterol)
COPD B (Gold 1-2, mod-severe sx)
Short acting bronchodilator (albuterol) +
Long acting bronchodilator (ipratropium, maybe long acting B2 agonist)
COPD C (Gold 3-4, mild sx)
Short acting bronchodilator (albuterol) +
Long acting bronchodilator (ipratropium, maybe long acting B2 agonist) +
Inhaled corticosteroids
COPD D (Gold 3-4, mod-severe sx)
Short acting bronchodilator (albuterol) +
Long acting bronchodilator (ipratropium, maybe long acting B2 agonist) +
Inhaled corticosteroids +/-
Theophylline, home O2 if indicated, PDE4 inhibitor (roflumilast)
Bronchiectasis
Pulmonary hygiene including chest PT
Antibiotics for increased sputum
B2 agonists/corticosteroids for symptoms
Resection of diseased lung segments
Superior vena cava syndrome
Steroids, stent
Tumor removal
Non-small cell lung cancer w/o metastasis
Surgical resection
Adjuvant chemo, radiation
Non-small cell lung cancer w/ LN
Radiation
Consider surgery, chemo
Non-small cell lung cancer w/ metastasis
Palliative
Small cell lung cancer
Chemo
Radiation (adjuvant)
Laryngeal cancer
Laryngectomy
Radiation, chemo
Idiopathic pulmonary fibrosis
Steroids
Azathioprine or cyclophosphamide
N-acetylcysteine
Lung transplant
Sarcoidosis
Occasionally self-resolving
Steroids, cytotoxic drugs, rarely transplant
Pneumoconioses
Usu no successful treatment (steroids may help)
Goodpasture syndrome
Plasmapheresis
Corticosteroids and immunosuppressants
Granulomatosis w/ polyangiitis (Wegener)
Cytotoxic (cyclophosphamide) and steroids
Pulmonary embolism
Supplemental O2 IVF or pressors if needed for hypotension AC w/ LMWH or warfarin 3-6 months IVC if AC C/I Possible thrombolysis
Pulmonary HTN
Supplemental O2
Vasodilators to decrease pulm vascular resistance (prostanoids, endothelin receptor antagonists/-sentans, PDE inhibitors/sildenafil, DHP CCB/nifedipine)
AC to decrease risk of pulm thrombus formation
Diuretics for pulm congestion
Pulm edema
Treat like CHF (NO LIP)
Nitrates, O2 if hypoxic, Loop diuretics, Inotropes (last ditch), Positioning
Pleural effusion
Treat underlying condition
Thoracocentesis and CT relieve pressure
CT required for empyema
Pleurodesis if recurrent malignant
Closed pneumothorax, <15%
Supplemental O2, observe
Closed pneumothorax, >15%
CT
Open PTX, small wound
CT + occlusive dressing
Open PTX, larger wound
Attempted closure, low threshold for intubation
Tension pneumothorax
Immediate needle decompression and CT
Recurrent PTX
Maybe pleurodesis
Hemothorax
O2, CT, treat underlying cause
Malignant mesothelioma
Surgery, chemo, radiation -> all have poor prognosis
Sleep apnea
Weight loss
No sedatives (including alcohol)
CPAP
Surgery
Atelectasis
IS, early ambulation, PT
Upper airway suctioning
Lower airway suctioning w/ bronchoscopy
Croup
Supportive care (humidified/cool air) Inhaled steroids, epinephrine (if stridor)
Epiglottitis
Intubation
IV abx 7-14 days
Bronchiolitis
Supportive care
Inhaled albuterol, epinephrine
Respiratory distress syndrome of the newborn
Corticosteroids before labor if <37 wks)
Surfactant replacement therapy
Meconium aspiration syndrome
Suction nose, mouth, upper airway
Supplemental O2, intubate if needed
Surfactant therapy may help
Empiric abx if concerned about PNA
Cystic fibrosis
B2 agonists, DNAse I, chest PT
Antibiotics PRN (Azithromycin, fluoros)
Pancreatic enzymes and vitamins A, D, E, K
Hepatitis A
Self limited, supportive care
Vaccine before travel
Hepatitis B
HBV immediately after exposure in unvaccinated pt
IFN-a
Antivirals (lamivudine, adefovir, entacavir)
Hepatitis C
IFN-a
Consider ribavirin
Hepatitis D
IFN-a
Hepatitis E
Self-limited, supportive care
Salivary gland disorders
Warm compresses, massage, lemon drops (ductal stones)
Abx and hydration (infx)
Surgery (refractory)
Achalasia
Nitrates and DHP CCB (rarely used)
Pneumatic dilation
Botulinum injections
Myotomy
Diffuse esophageal spasm
CCP, nitrates, TCAs
Zenker diverticulum
Cricopharyngeal myotomy or diverticulectomy
GERD
Elevate HOB, weight loss, dietary modification
Antacids
H2 blockers or PPIs
Nissen fundoplication or hiatal hernia repair (refractory)
Esophageal cancer
Surgical resection (early)
Radiation/chemo (nonoperative or adjuvant)
Poor prognosis
Hiatal hernia
Sliding - reflux control
Paraesophageal - surgery (gastropexy, Nissen fundoplication)
Gastritis
Stop alcohol/medications
H2 blockers/PPIs
Type A - vitamin B12
Type B - PPI + clarithromycin + amoxicillin or metronidazole 10-14 days
PUD
R/o active bleeding (CBC, EGD, stool guiaic)
PPI/H2 antagonist to decrease gastric acid
Sucralfate, bismuth subsalicylate, misoprostol (NSAID use) to protect mucosa
Surgery for acute perforation, refractory
Zollinger-Ellison syndrome
Surgical resection if localized
PPI/H2 blockers
Octreotide in metastatic
Gastric cancer
Subtotal gastrectomy (distal third of stomach) Total gastrectomy (upper/middle stomach, invasive) Radiation/chemo as adjuvants