Treatment Of Rheumatic Diseases Flashcards
Mention a cox 2 inhibitor
Celecoxib
MOA of methotrexate
folate pathway antagonist by
inhibiting dihydrofolate reductase (DHFR) enzyme,
resulting in inhibition of purine synthesis and thus
arrest in the S phase of the cell cycle eventually
leading to apoptosis
What is the drug that must be given with MTX
Folate 1mg/day
Contraindication of MTX
. Renal impairment (CrCl<30 ml/min)
. Pregnancy (stop 3 months before conception)
. Lactation
MOA of Leflunamide
inhibits dihydroorotate dehydrogenase
resulting in decrease in synthesis of pyrimidines
Drug used for washout of leflunamide
cholestyramine
When should leflunamide be stopped before conception
3 months as it is teratogenic
Least toxic DMRADS
Hydroxychloroquine
MOA of Hydroxychloroquine
decrease
production of IL-1, IL-6 and interferons. In addition
antimalarials help to lower lipid levels and decrease
platelet aggregation
Eye complication of hydroxychloroquine
Maculopathy
When using DMRADS,
CBC, ALT, AST and creatinine should be done at
…….. and then CBC, liver and kidney functions
should be done every……..
. At baseline
. 8-12 weeks
Mosy important indication of sulfasalazine
Seronegative spondyloarthropathies
MOA of cyclophosphamide
Alkylating agent
A pt starts cyclophosphamide for SLE, what should happen to the initial dose if he has a renal disease as well?
Initial
dose is decreased by 30% if CrCL<30ml/min
MOA of cyclosporine
inhibition of T cell activation through
inhibiting the transcription factor needed to
activate IL-2.
