Raynaulds, Scleroderma And Inflammatory Myopathy

Question 1

What is the difference in nails fold capilloroscopy and serology between 1ary and autoimmune Raynauld phenomena?

Answer 1

In 1ary : no abnormalities
In autoimmune: there might be some abnormalities

Question 2

Antibody involved in pathogenesis of scleroderma

Answer 2

Anti-topoisimerase 1 (anti-Scleroderma 70) (anti-Sc 70)

Question 3

Treatment of pulmonary fibrosis in scleroderma

Answer 3

Depends on severity:
I. N-acetylcysteine
II. Mycophenolate mofetil or Azathioprine
III. Iv Cyclophosphamide (monthly) + oral steroids
IV. Rituximab

Question 4

Medical Tx of scleroderma complicated by renal disease

Answer 4

• Review/initiate ACE inhibitor
• Start iloprost-continuous low dose if tolerated