Treatment of RA: adverse reaction Flashcards

1
Q

Corticosteroids (CS)

A

Cataracts, glaucoma, thinned skin, striae, diabetes, hirsutism, acne, hypertension, weight gain, HPA axis suppression, myopathy, GI, cardiovascular, infectious, neurologic complications, osteonecrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Methotrexate (MTX)

A
  • Hepatotoxicity
  • Pulmonary toxicity
  • Fetal abnormalities
  • Gastrointestinal, stomatitis, hematologic, rash, alopecia, CNS effects, Nephrotoxicity, rash, oligospermia, gynecomastia, localized osteoporosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Sulfasalazine (SAS, SSZ)

A
  • GI effects common,

- rash, photosensitivity, Dizziness, headache, reversible oligospermia, megaloblastic, hemolytic, aplastic anemias

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Leflunomide (Arava)

A
  • Increased liver enzymes
  • Teratogenicity
  • GI (diarrhea, nausea, abdominal pain), hypertension, reversible alopecia, rash, headache, paresthesias, Stevens-Johnson syndrome, toxic epidermal necrolysis, bone marrow suppression
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Hydroxychloroquine

A
  • Retinal damage

- GI side effects, rash, insomnia, myopathy, rarely leukopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Minocycline

A

Hyperpigmentation, photosensitivity, dizziness, vaginal yeast infection; may decrease efficacy of oral contraceptives

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Cyclosporine (CY)

A
  • Nephrotoxicity
  • hypertension
  • gingival hyperplasia
  • hyperkalemia
  • hyperuricemia
  • hypomagnesemia, gastrointestinal problems, neuropathies, hirsutism
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Azathioprine

A
  • leukopenia (dose related)

- Gastrointestinal upset, thrombocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Gold

A

Toxicity, diarrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

D-penicillamine

A

Toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Cyclophosphamide

A

Toxicity, risk of malignancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Tofacitinib

A
  • Increased LDL cholesterol
  • increased LFTs
  • GI perforation
  • Herpes zoster
  • neutropenia/bone marrow suppression, headache, diarrhea, Tb
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Baricitinib

A
  • Increased LDL cholesterol
  • increased LFTs
  • GI perforation
  • Herpes zoster
  • neutropenia/bone marrow suppression, headache, diarrhea, Tb
  • black box warning about thrombosis (DVT, PE, arterial)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Etanercept

A

Injection site reactions (rash); upper respiratory tract symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Infliximab

A

Acute infusion reactions, hypersensitivity, increased infection risk, + ANA, lupus (rare), leukopenia, neutropenia, thrombocytopenia, pancytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Adalimumab

A

Injection site or allergic reactions, headache, rash, sinusitis

17
Q

Golimumab

A

Upper respiratory infection, sore throat, nasal congestion

18
Q

Certolizumab pegol

A

Upper respiratory & other infections, headache, nausea, diarrhea

19
Q

Rituximab

A

Infusion reactions, neutropenia, lymphopenia, thrombocytopenia, anemia, weakness, serious infections, and mucocutaneous reactions; reactivation of hepatitis B; warning about progressive multifocal leukoencephalopathy

20
Q

Abatacept

A
  • COPD exacerbations

- Serious infections, infusion-related reactions

21
Q

Tocilizumab

A
  • GI perforation
  • upper respiratory infections, nasopharyngitis, headache, hypertension, ↑ liver enzymes / lipids, decreased neutrophils / platelets, infections
22
Q

Sarilumab

A

↑ liver enzymes / lipids, decreased neutrophils / platelets, infections,

23
Q

Anakinra

A

neutropenia, serious infections, injection site reactions – dose-related skin irritation