IBD Drugs

Question 1

Sulfasalazine ADE

Answer 1

GI upset, rash, headache, arthralgias, hypersensitivity, aplastic anemia, fever, hepatotoxicity

Question 2

Sulfasalazine Counseling

Answer 2

Take with food.
Improvement takes 4+ weeks; extended release agents
should not be crushed or chewed. Impairs folic acid absorption

Question 3

Mesalamine ADE

Answer 3

Headache, abdominal pain, nausea, eructation, edema, dizziness, fever, pharyngitis

Question 4

Mesalamine Counseling

Answer 4

Extended release agents should not be crushed or chewed; avoid antacids, H2RAs, PPIs

Question 5

Olsalazine ADE

Answer 5

dose-related secretory diarrhea

Question 6

Balsalazide ADE

Answer 6

headache, abdominal pain

Question 7

Corticosteroids ADE

Answer 7

HPA axis suppression, increased risk of infection, immunosuppression, ↑glucose, ↑WBC, ↑ BP, weight gain, edema, alteration in mood/insomnia, osteoporosis (long term)

Question 8

Corticosteroids Counseling

Answer 8

take oral preps with food to decrease stomach upset, do not stop abruptly

Question 9

Azathioprine ADE

Answer 9

hepatosplenic T-cell lymphoma, n/v/d, infection, neutropenia, hair loss, pancreatitis, hepatotoxicity, nephrotoxicity, myelosuppression

Question 10

Mercaptopurine ADE

Answer 10

hepatosplenic T-cell lymphoma, infection, neutropenia, nausea, hair loss, pancreatitis, hepatotoxicity, myelosuppression

Question 11

Cyclosporine ADE

Answer 11

hypertrichosis, n/v, hyperglycemia, nephrotoxicity, HTN, hepatotoxicity, neurological toxicity, headache, infection, hyperuricemia

Question 12

Methotrexate ADE

Answer 12

myelosuppression, hepatotoxicity, pulmonary toxicity

Question 13

Metronidazole ADE

Answer 13

metallic taste, disulfiram-like reaction, nausea, paresthesias, glossitis, peripheral neuropathy with long-term use

Question 14

Metronidazole Counseling

Answer 14

disulfiram-like reaction with alcohol

Question 15

Ciprofloxacin Counseling

Answer 15

avoid taking with Ca2+ or iron products, vitamins, dairy

Question 16

Infliximab ADE

Answer 16

infection, infusion reaction, fever, myalgias, hepatosplenic T-cell lymphoma, headache, nausea, diarrhea

Question 17

Adalimumab ADE

Answer 17

infections, injection site reaction, headache, rash, hepatosplenic T-cell lymphoma, elevated CK

Question 18

Certolizumab pegol ADE

Answer 18

infections, arthralgias, hepatosplenic T-cell lymphoma, headache

Question 19

Tysabri: Leukocyte Adhesion and Migration Inhibitors ADE

Answer 19

PML (progressive multifocal leukoencephalopathy), URI, headache, nausea, fatigue