Treatment of anaemia tutorial Flashcards
where is iron best absorbed
duodenum/proximal jejunum
what safely transports the iron to bone marrow
transferrin
How quickly would you expect Hb to rise on ferrous fumarate?
5-10g/per week
if Hb isn’t rising as quickly as expected on ferrous fumarate, how do we work out whether it’s a problem with blood loss or with compliance?
reticulocyte count
problems with compliance on ferrous fumarate - how can we fix this
- symptom control e.g. laxatives
- alternative dosing/alternative oral iron
- IV iron if needed
Where does the absorption of the B12-Intrinsic factor complex take place?
ileum
treatment of macrocytic anaemia - pernicious anaemia
Intramuscular B12 (IM hydroxocobalamin)
Pernicious anaemia – 2-3 monthly injections for life
Other than Pernicious anaemia what else might result in B12 deficiency?
- bariatric surgery
- crohns
- coeliac
where is folate absorbed
jejunum
how long do folate stores last?
about 3 months
what does serum folate tell us
how much folate they’ve had in the last couple of days
