Haemopoiesis

Question 1

what is a blast

Answer 1

nucleated precursor cell

Question 2

megakaryocytes are polypoid, true or false

Answer 2

true

Question 3

polychromasia

Answer 3

more immature red blood cells than what’s considered normal (reticulocytes)

Question 4

what are Myelocytes

Answer 4

nucleated precursor between neutrophils and blasts

Question 5

how do haemopoietic stem cells renew

Answer 5

one daughter cell is exactly the same as the parent, the other goes and differentiates
?

Question 6

bone marrow haemopoiesis starts by week ____ in foetus

Answer 6

16

Question 7

red vs yellow marrow

Answer 7

red - haemopoietically active
yellow - fatty inactive

Question 8

what happens to amount of yellow marrow with age

Answer 8

increases
results in reduction in marrow cellularity in older individuals

Question 9

what is meant by the Myeloid:erythroid ratio

Answer 9

relationship of neutrophils and precursors to proportion of nucleated red cell precursors (ranges from 1.5:1 to 3.3:1) – can change (eg reversal in haemolysis as a compensatory response)

Question 10

neutrophil precursor maturation is regulated by _______

Answer 10

G-CSF (granulocyte-colony stimulating factor)

Question 11

___________ regulates growth and development of megakaryocytyes from their precursors

Answer 11

Thrombopoietin

Question 12

immunophenotyping

Answer 12

the study of antigen expression using specific antibodies