Treating CVD

Question 1

What is central to cardiovascular disease and its treatment?

Answer 1

Atherosclerosis

Question 2

What does primary prevention allow?

Answer 2

Keeps the disease from being established

Question 3

What does secondary prevention allow?

Answer 3

Interrupts the disease process before it becomes symptomatic

Question 4

What does tertiary prevention allow?

Answer 4

Limits the physical and social consequences of symptomatic disease

Question 5

What are statins used for?

Answer 5

Primary prevention, reducing serum cholesterol by reducing hepatic cholesterol synthesis

Question 6

What are two other actions of statins?

Answer 6

Anti-thrombotic

Improve endothelial function

Question 7

What is aspirin?

Answer 7

Irreversible inhibitor of COX1. Limits thrombus formation and so reduces the incidence of heart attacks/strokes in those with atherosclerosis.

Question 8

What does arachidonic acid break down into with addition of COX1?

Answer 8

Prostaglandin I2 and thromboxane A2

Question 9

What do ACE inhibitors act on?

Answer 9

Renin-angiotensin system by blocking AngiotensinI being converted into angiotensinII causing fluid retention and vasoconstriction. Used to treat hypertension and heart failure.