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BMSC1212 Introduction to pharmacology > Antivirals > Flashcards

Antivirals Flashcards

1
Q

What is the tissue tropism for neuronal cells?

A

Neurotropic

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2
Q

What is the tissue tropism for the upper and lower respiratory tract?

A

Pneumotropic

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3
Q

What is the tissue tropism for lymphatic cells?

A

Lymphotropic

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4
Q

What is the tissue tropism for gut epithelial cells?

A

Enterotropic

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5
Q

What sort of receptors does flu need?

A

Sialic acid

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6
Q

What are PAMPs?

A

Pathogen-associated molecular patterns

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7
Q

What are 3 antiviral methods?

A
  1. Blocks steps in the process through which viruses reproduce
  2. Stimulate the immune system
  3. Target host cell components that the virus requires.
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8
Q

What is a lentivirus?

A

A slowly replicating retrovirus

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9
Q

What does HIV do to cells?

A

Binds to CD4 receptors on T-cells and causes apoptosis of uninfected bystander cells. Cell-mediated immunity is lost.

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10
Q

What is HAART?

A

Highly active anti-retroviral therpy.

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11
Q

What does HIV treatment combine?

A

RTIs and proteinase inhibitors.

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12
Q

What two pills are given to treat HIV?

A

Sustiva and Truvada

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13
Q

What does Truvada combine?

A

Emtriva and Viread

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14
Q

What group is the influenza virus in?

A

Orthomyxoviridae

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15
Q

What does influenza virus A infect?

A

Humans, pigs, birds, horses and aquatic mammals.

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16
Q

What does influenza virus B infect?

A

Humans only

17
Q

What does influenza virus C infect?

A

HUmans and pigs

18
Q

What are the primary sites of infection?

A

Epithelial cells lining the entire respiratory tract.

19
Q

What shape is the influenza virus?

A

Pleomorphic, can be rod-shaped

20
Q

How many RNA segemnts are included on the virus’ exterior?

A

8

21
Q

What does DAS181 do?

A

Cleaves the sialic acid linkages on human epithelial cells.

22
Q

what are adamantanes?

A

M2 channel blockers which inhibit proton entry through the channel into the virion

23
Q

What does favipiravir do?

A

Inhibits the viral RNA-dependent RNA polymerase

24
Q

Name two drugs very similar to sialic acid

A

Tamiflu and Relenza

BMSC1212 Introduction to pharmacology (17 decks)

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